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Record W4409857686 · doi:10.1002/mef2.70019

The Use of Large Language Models and Their Association With Enhanced Impact in Biomedical Research and Beyond

2025· article· en· W4409857686 on OpenAlexaff
Huzi Cheng, Wen Shi, Bin Sheng, Aaron Lee, Josip Car, Varun Chaudhary, Atanas G. Atanasov, Nan Liu, Yue Qiu, Qingyu Chen, Tien Yin Wong, Yih Chung Tham, Yingfeng Zheng

Bibliographic record

VenueMedComm – Future Medicine · 2025
Typearticle
Languageen
FieldComputer Science
TopicTopic Modeling
Canadian institutionsMcMaster UniversityImpact
FundersNational Key Research and Development Program of ChinaNational Natural Science Foundation of China
KeywordsAssociation (psychology)Computer sciencePsychologyData sciencePsychotherapist

Abstract

fetched live from OpenAlex

ABSTRACT The release of ChatGPT in 2022 has catalyzed the adoption of large language models (LLMs) across diverse writing domains, including academic writing. However, this technological shift has raised critical questions regarding the prevalence of LLM usage in academic writing and its potential influence on the quality and impact of research articles. Here, we address these questions by analyzing preprint articles from arXiv, bioRxiv, and medRxiv between 2022 and 2024, employing a novel LLM usage detection tool. Our study reveals that LLMs have been widely adopted in biomedical and other types of academic writing since late 2022. Notably, we noticed that LLM usage is linked to an enhanced impact of research articles after examining their correlation, as measured by citation numbers. Furthermore, we observe that LLMs influence specific content types in academic writing, including hypothesis formulation, conclusion summarization, description of phenomena, and suggestions for future work. Collectively, our findings underscore the potential benefits of LLMs in scientific communication, suggesting that they may not only streamline the writing process but also enhance the dissemination and impact of research findings across disciplines.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.023
metaresearch head score (Gemma)0.188
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Bibliometrics
Consensus categoriesnone
DomainCandidate signal: Evaluation · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.991
Threshold uncertainty score0.123

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0230.188
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0090.009
Science and technology studies0.0010.002
Scholarly communication0.0070.006
Open science0.0010.003
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0040.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.030
GPT teacher head0.342
Teacher spread0.312 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designObservational
DomainEvaluation
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes1
Has abstractyes

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