Madrid Sonographic Enthesis Index (MASEI) Assessment in Radiographic Axial Spondyloarthritis (r-axSpA) Patients: Association with Clinical Activity and Outcome Scores
Bibliographic record
Abstract
Background: Axial spondyloarthritis (axSpA) refers to chronic inflammatory arthritis primarily impacting the spine, resulting in pain and stiffness. It is classified as either radio-graphic axSpA (r-axSpA), previously known as ankylosing spondylitits (AS), or nonradiographic axSpA (nr-SpA). This study aimed to evaluate the validity of the ultrasound (US) en-thesis score in comparison with clinical disease outcome meas-ures for assessing disease outcome in patients with radiograph-ic axial spondyloarthritis (r-axSpA). Patients and Methods: A cross-sectional study was carried out on 84 individuals divided into 2 groups: r-axSpA patient group of 42 patients and control group of 42 healthy individu-als. Clinical scores: Bath Ankylosing Spondylitis disease activ-ity index (BASDAI), AS disease activity score (ASDAS), Bath AS metrology index (BASMI), Bath Ankylosing Spondylitis functional index (BASFI), health assessment questionnaire (HAQ), and spondyloarthritis research consortium of Canada (SPARCC) to evaluate 16 entheseal sites were assessed. Ultra-sonography was done using total and subdomains of the Madrid Sonographic Enthesitis Index (MASEI) for assessments. Results: R-axSpA patients had significantly higher abnor-mal entheses by ultrasound than control 42/504 (8.3%) vs 12 (2.3%) (p<0.001). MASEI score was 1.88±3.27 (0-12), inflam-matory MASEI score was 0.31±0.68 (0-3), and damage MASEI score was 1.57±3.16 (0-12) in r-axSpA patients. Damage MA-SEI score was significantly worse in the r-axSpA group than the control group (p=0.007). A significant correlation was observed among [total MASEI score and HAQ (p=0.036) and BASMI (p<0.001)] and between [damage MASEI score and BASMI (p=0.001), HAQ (p=0.031)]. Patients on secukinumab had significantly lower damage MASEI. There was no significant relation between total, inflammatory or damage MASEI scores with etanercept and adalimumab. Conclusions: The examination of entheses via ultrasound may serve as a valuable complement to clinical evaluation, necessitating further research to determine its diagnostic and follow-up roles in disease progression.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.003 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".