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Record W4409958637 · doi:10.1101/2025.04.26.25326493

Effectiveness of Relaxation Therapy for Wound Healing in Patients with Diabetic Foot Ulcers: A Systematic Review of Randomized Control Trials

2025· review· en· W4409958637 on OpenAlexaff
Daanyal Noor Farrukh, Misbah Munaf Gaurd, Fiza Farrukh-Hassan

Bibliographic record

VenuemedRxiv · 2025
Typereview
Languageen
FieldMedicine
TopicDiabetic Foot Ulcer Assessment and Management
Canadian institutionsMcMaster University
Fundersnot available
KeywordsDiabetic footMedicineWound healingRandomized controlled trialSystematic reviewSurgeryDiabetes mellitusMEDLINE

Abstract

fetched live from OpenAlex

Abstract Diabetic foot ulcers (DFU) is a serious complication of diabetes that leads to open sores found on the lower extremity, ultimately decreasing the quality of life. The purpose of this study is to systematically review randomized control trials (RCTs) to evaluate the effectiveness of relaxation therapy on healing wounds in patients with diabetic foot ulcers. The search was conducted across the databases of PubMed, Embase (Ovid), Cochrane Library, Google Scholar, and Web of Science. Inclusion criteria consisted of RCTs that compared relaxation therapy to standard care or other psychological/psychosocial intervention. The primary outcomes looked at were DFU healing, DFU extent, and perceived stress scale. The study included 3 RCTs that enrolled 75 patients with diabetic foot ulcers. It was found that within-intervention, relaxation therapy led to improved DFU healing, DFU extent, and participants were less stressed. Despite this, no evidence was found that suggested that relaxation therapy significantly improves outcomes compared to standard care or neutral imagery. Overall, it cannot be concluded that relaxation therapy has an effect on outcomes as there isn’t enough RCTs to come to a conclusion. Future research should delve into long-term effects of relaxation therapy on wound healing in patients with DFU, as well as compare it to other implemented therapies, such as cognitive behavioral therapy.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.013
metaresearch head score (Gemma)0.050
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Systematic review · Consensus signal: Systematic review
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.013
Threshold uncertainty score0.068

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0130.050
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0120.009
Bibliometrics0.0050.006
Science and technology studies0.0010.001
Scholarly communication0.0020.002
Open science0.0020.001
Research integrity0.0020.002
Insufficient payload (model declined to judge)0.0050.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.026
GPT teacher head0.345
Teacher spread0.319 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSystematic review
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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