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Record W4410092597 · doi:10.1101/2025.05.04.651766

Function of the auditory cortex characterized by its intrinsic dynamic coactivation patterns estimated in individuals

2025· preprint· en· W4410092597 on OpenAlexfundno aff
Maria Hakonen, Kaisu Lankinen, Parker Kotlarz, Jon̈athan R. Polimeni, Tori Turpin, Jianxun Ren, Dong Wang, Hesheng Liu, Jyrki Ahveninen

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2025
Typepreprint
Languageen
FieldNeuroscience
TopicNeural dynamics and brain function
Canadian institutionsnot available
FundersCanadian Institutes of Health ResearchChina Postdoctoral Science FoundationMassachusetts Life Sciences CenterChangping Laboratory
KeywordsCoactivationFunction (biology)Auditory cortexPsychologyNeuroscienceAudiologyBiologyMedicineElectromyographyEvolutionary biology

Abstract

fetched live from OpenAlex

Determining the functional organization of the auditory cortex (AC) has been difficult with conventional task-based approaches due to the broad responsiveness of auditory subregions to various acoustic properties. Moreover, most studies have investigated functional organization of AC with static methods, although brain has shown to be organized into dynamic networks. Here, we investigated dynamically varying coactivation patterns of the local networks in the auditory cortex (AC) determined from 7T fMRI data with a novel individualized network-based algorithm. An eight-pattern solution was selected for closer examination based on its high reproducibility of the occurrence rates (r=0.86) and the spatial topography (r=0.79) between sessions. Dynamic AC patterns successfully captured interindividual variability, as indicated by significantly higher variability between than within individuals for the AC pattern occurrence rates and spatial topographies. The coactivation patterns shared similarities between resting-state and auditory-task data, as indicated by the group-level similarity of 0.84 and individual-level similarity of 0.71 in the spatial topographies. Furthermore, the occurrence rates of AC patterns identified in the task data, using pattern templates derived from resting-state data, correlated with specific task contrast regressors. Our results indicate that the AC function can be characterized by a set of dynamically varying coactivation patterns that are consistently observed during resting state and auditory stimulation, and that get synchronized with auditory input. These findings enhance our understanding of the relationship between spontaneous and stimulus-driven activity in the AC and support the development of more time-efficient paradigms for studying its functional organization.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.002

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.016
GPT teacher head0.231
Teacher spread0.214 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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