The Pre-Twin Screen Consortium proposal for fetal structural anomalies evaluation across all three trimesters in twin pregnancies
Bibliographic record
Abstract
PURPOSE: In singleton pregnancies, routine ultrasound examinations in each trimester improves the diagnosis of fetal abnormalities and their management. In this study, we examine twin pregnancies and report on the detection of fetal anomalies in each trimester and postnatally as well as on the type of anomalies and their prevalence. METHODS: This prospective multicenter study enrolled pregnant women with dichorionic (DC) and monochorionic diamniotic (MCDA) twins at gestational weeks (GA) 11 + 0 to 13 + 6 in six medical centers (two in Germany, and one each in Spain, Canada, Italy, and Israel). Pregnancies were dated by the crown-rump length of the larger twin. Detailed scans were performed according to the guidelines of the International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) at enrollment at gestational week (GA) 11 + 0 to 13 + 6, and at GA 20 + 0 to 22 + 6 and GA 28 + 0 to 32 + 6. Neonatal examinations were conducted in each case. Malformations were confirmed after delivery or postmortem in cases of fetal death or termination of pregnancy (TOP). RESULTS: Of the 649 twin pregnancies (1298 live fetuses) at enrollment, there were 436 (70.6%) DC and 182 (29.4%) MCDA pregnancies. In total, 1168 babies were liveborn to 618 mothers (808 DC and 360 MCDA twins) after excluding cases lost to follow-up and TOPs. Anomalies were identified in 4.1% of the fetuses (48/1168). Of the 48 fetuses with anomalies, 17 (35.4%) were identified in the first, 21 (43.8%) in the second, and 6 (12.5%) in the third trimester. Additional 4 (8.3%) were identified postnatally. Of the anomalies, 37 were in fetuses from DC twins (4.57%), and 11 (3.05%) in MCDA twins. CONCLUSION: We demonstrate the utility of detailed fetal scans in twin pregnancies in all three trimesters. First- and second-trimester diagnosis enables genetic counseling and testing, and informed parental decisions of pregnancy management. In addition to alerting the parents to the presence of fetal anomalies, third-trimester scans enhanced delivery planning and newborn care.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.018 | 0.020 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.004 | 0.002 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.003 | 0.003 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".