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Record W4410248774 · doi:10.1080/22311866.2025.2493088

The effects of topical <i>Achillea millefolium</i> oil in patients with knee osteoarthritis: A randomized double-blind active-controlled clinical trial

2025· article· en· W4410248774 on OpenAlexaboutno aff
Mitra Abbasifard, Gholamreza Bazmandegan, Fatemeh Ayoobi, Puria Najmaddini, Zahra Kamiab

Bibliographic record

VenueJournal of Biologically Active Products from Nature · 2025
Typearticle
Languageen
FieldAgricultural and Biological Sciences
TopicEssential Oils and Antimicrobial Activity
Canadian institutionsnot available
Fundersnot available
KeywordsAchillea millefoliumOsteoarthritisMedicineRandomized controlled trialDouble blindClinical trialPhysical therapyInternal medicineTraditional medicineAlternative medicinePathology

Abstract

fetched live from OpenAlex

Knee osteoarthritis is the leading causes of disability. In this study, the topical effect of Achillea millefolium oil on pain intensity and functional indices in patients with knee osteoarthritis was investigated. In this double-blind randomized clinical trial, 90 patients with knee osteoarthritis referred to the Rafsanjan Rheumatology Clinic were randomly divided into three groups: topical piroxicam 0.5% gel, A. millefolium oil, and paraffin ointment (placebo). The diagnosis of the disease was made by a rheumatology specialist based on the criteria of the American College of Rheumatology. pain Visual Analogue Scale (VAS) and the Western Ontario and McMaster (WOMAC) index, before intervention, one and two months after it were assessed. Data were analyzed using SPSS.24 software and a significance level of 0.05. The mean of age and frequency of gender were not significantly difference between the three groups of A. millefolium oil, piroxicam gel, and placebo (P=0.914 and P=0.189 respectively). There was a significant difference in the mean of pain VAS (F = 23.173, P <0.001) and WOMAC (F = 35.098, P <0.001) over time (12 weeks). According to the results of this study, the effect of the A. millefolium plant in reducing pain intensity and improving the functional status of patients can reduce the need for the use of other chemical drugs.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.004
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.125
Threshold uncertainty score0.665

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.004
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.248
Teacher spread0.241 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

Explore more

Same venueJournal of Biologically Active Products from NatureSame topicEssential Oils and Antimicrobial ActivityFrench-language works237,207