Cross‐Ancestry Associations of Spontaneous Coronary Artery Dissection Genetic Risk With Coronary Atherosclerosis and Migraine Headache
Bibliographic record
Abstract
Background Research studies of spontaneous coronary artery dissection (SCAD) have been primarily focused on European‐ancestry individuals, with limited recognition and investigation in non–European‐ancestry individuals. While SCAD has not been well ascertained in non–European‐ancestry groups, pleiotropic associated traits identified in those of European ancestry have been assessed in individuals of other ancestries. Whether these traits are associated with the complex genetic architecture of SCAD in those of non‐European ancestry has not been previously investigated. Methods We investigated the associations of an established SCAD polygenic score with multiple vascular diseases in ≈900 000 ancestrally diverse participants of large‐scale studies. Individual‐level data from the UK Biobank and the Million Veteran Program and summary statistics of publicly available databases were analyzed. Results A set of associations between SCAD polygenic score and related vascular diseases were replicated in non‐European samples. Notable associations with the SCAD polygenic score included (1) coronary artery disease, myocardial infarction, and migraine headache in a Hispanic group (coronary artery disease: odds ratio [OR], 0.93 [95% CI, 0.90–0.95]; P =2.35×10 −7 ; myocardial infarction: OR, 0.88 [95% CI, 0.80–0.96]; P =5.73×10 −3 ; migraine headache: OR, 1.03 [95% CI, 1.01–1.06]; P =1.86×10 −2 ) of the Million Veteran Program; (2) headache in an African‐ancestry group (OR, 1.22 [95% CI, 1.06–1.41]; P =6.94×10 −3 ) and a South Asian–ancestry group (OR, 1.18 [95% CI, 1.02–1.37]; P =2.43×10 −2 ) of the UK Biobank; and (3) coronary artery disease, myocardial infarction, and migraine headache in East Asian–ancestry cohorts (coronary artery disease: OR, 0.95 [95% CI, 0.93–0.98]; P =2.66×10 −3 ; myocardial infarction: OR, 0.86 [95% CI, 0.83–0.89]; P =9.51×10 −16 ; migraine headache: OR, 1.27 [95% CI, 1.10–1.47]; P =1.03×10 −3 ). Conclusions Pleiotropic associations of SCAD polygenic risk with related vascular diseases previously identified in European‐ancestry groups showed notable, largely consistent patterns in non–European‐ancestry groups.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".