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Record W4410335221 · doi:10.1016/j.jbc.2025.110220

Guard cell and whole plant expression of AtTOR improves performance under drought and enhances water use efficiency

2025· article· en· W4410335221 on OpenAlexafffund
Li Liu, Peng Gao, Huajin Sheng, Achala Bakshi, David J. Schneider, Daoquan Xiang, Vivijan Babic, Connor Burbridge, Hanh Nguyen, Sheng Wang, Alma Armenta-Medina, Javier Mora‐Macias, Andrew Sharpe, Curtis Pozniak, J. V. de Magalhães, Raju Datla, Leon V. Kochian

Bibliographic record

VenueJournal of Biological Chemistry · 2025
Typearticle
Languageen
FieldAgricultural and Biological Sciences
TopicPlant Stress Responses and Tolerance
Canadian institutionsNational Research Council CanadaSaskatchewan Research Council (Canada)Global Institute for Water SecurityUniversity of Saskatchewan
FundersCanada Excellence Research Chairs, Government of CanadaCanada First Research Excellence FundUniversity of SaskatchewanAgricultural Research ServiceBiology Department, Gannon UniversityNational Research Council CanadaCornell University
KeywordsGuard cellExpression (computer science)Guard (computer science)CellWater stressCell biologyEnvironmental scienceChemistryBiologyComputer scienceAgronomyBiochemistry

Abstract

fetched live from OpenAlex

Water use efficiency is an important target for breeding of improved drought resistance. Minimizing leaf transpirational water loss plays a key role in drought resistance. But this reduces CO 2 levels in leaves, which often reduces photosynthetic efficiency and yield. Signaling pathways play important roles in stress responses, and identifying the molecular, biochemical, and physiological determinants underlying drought signaling may offer new drought mitigating strategies. To explore these possibilities, and because of the importance of stomata in drought response and photosynthesis, we employed guard cell (GC) targeted and constitutive overexpression of the Target of Rapamycin (TOR) kinase, a master regulator of signaling networks, in transgenic Arabidopsis. To investigate the impact of these AtTOR transgenes in drought, we conducted physiological and molecular investigations into drought responses, including leaf water loss, photosynthetic CO 2 assimilation, stomatal H 2 O/CO 2 conductance, , leaf chlorophyll content, and global gene expression in response to drought in wild type and AtTOR expressing Arabidopsis. Links between both guard cell-localized and whole plant AtTOR overexpression were identified, revealing TOR is involved in conservation of water and sustained photosynthetic performance, along with identification of genes associated with drought response in WT vs. AtTOR- expressing transgenic lines. These findings suggest that targeted guard cell AtTOR expression should help achieve a balance between plant water conservation during drought, and maintaining plant performance, by minimizing reductions in photosynthesis. Manipulation of guard cell AtTOR expression could be an effective avenue for developing crops with enhanced drought resistance and increased yield under drought stress, resulting in enhanced water use efficiency.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.204
Teacher spread0.191 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

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