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Record W4410343249 · doi:10.1136/bmjebm-2025-113825

Reporting guideline for the use of Generative Artificial intelligence tools in MEdical Research: the GAMER Statement

2025· article· en· W4410343249 on OpenAlexaff
Xufei Luo, Yih Chung Tham, Mauro Giuffrè, Robert Ranisch, Mohammad Daher, Kyle Lam, Alexander Viktor Eriksen, Che-Wei Hsu, Akihiko Ozaki, Fábio Ynoe de Moraes, Sahil Khanna, Kuan‐Pin Su, Emir Begagić, Zhaoxiang Bian, Yaolong Chen, Janne Estill

Bibliographic record

VenueBMJ evidence-based medicine · 2025
Typearticle
Languageen
FieldMedicine
TopicArtificial Intelligence in Healthcare and Education
Canadian institutionsQueen's University
FundersChinese Academy of Medical SciencesLanzhou University
KeywordsDeclarationDelphi methodChecklistTransparency (behavior)DelphiComputer scienceGuidelineArtificial intelligenceMedical educationPsychologyData scienceMedicineComputer security

Abstract

fetched live from OpenAlex

OBJECTIVES: Generative artificial intelligence (GAI) tools can enhance the quality and efficiency of medical research, but their improper use may result in plagiarism, academic fraud and unreliable findings. Transparent reporting of GAI use is essential, yet existing guidelines from journals and institutions are inconsistent, with no standardised principles. DESIGN AND SETTING: International online Delphi study. PARTICIPANTS: International experts in medicine and artificial intelligence. MAIN OUTCOME MEASURES: The primary outcome measure is the consensus level of the Delphi expert panel on the items of inclusion criteria for GAMER (Rreporting guideline for the use of Generative Artificial intelligence tools in MEdical Research). RESULTS: The development process included a scoping review, two Delphi rounds and virtual meetings. 51 experts from 26 countries participated in the process (44 in the Delphi survey). The final checklist comprises nine reporting items: general declaration, GAI tool specifications, prompting techniques, tool's role in the study, declaration of new GAI model(s) developed, artificial intelligence-assisted sections in the manuscript, content verification, data privacy and impact on conclusions. CONCLUSION: GAMER provides universal and standardised guideline for GAI use in medical research, ensuring transparency, integrity and quality.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.335
metaresearch head score (Gemma)0.526
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesMetaresearch
DomainCandidate signal: Reporting · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.665
Threshold uncertainty score0.821

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.3350.526
Meta-epidemiology (narrow)0.0040.004
Meta-epidemiology (broad)0.0050.014
Bibliometrics0.0180.009
Science and technology studies0.0040.007
Scholarly communication0.0100.007
Open science0.0130.017
Research integrity0.0200.014
Insufficient payload (model declined to judge)0.0090.011

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.892
GPT teacher head0.659
Teacher spread0.233 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; the direct Gemma label and the distilled Codex classifier agree on what is shown here.

Study designNot applicable
DomainReporting
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations49
Published2025
Admission routes1
Has abstractyes

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Same venueBMJ evidence-based medicineSame topicArtificial Intelligence in Healthcare and EducationFrench-language works237,207