Prospective longitudinal cohort of Argentinean patients with progressive supranuclear palsy and corticobasal syndrome: A platform for epidemiological and translational research
Bibliographic record
Abstract
Background: Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) are neurodegenerative disorders with disabling postural instability, falls and cognitive impairment associated with 4-repeat tau protein neuropathology. The low prevalence (6/100,000 inhabitants) is estimated with data only from North American, European countries or Japan. Objective: A multicenter initiative for studying the epidemiology and tau biology of Argentinean patients with PSP and CBS and their ovelaps, Consorcio Argentino de Investigación Traslacional en Tauopatias Primarias (CAITauP). Methods: A prospective observational cohort of people with PSP (PwPSP), CBS and PSP/CBS overlaps will be longitudinally studied aiming at recruitment of 75 patients in 3 years. Deep clinical phenotyping, neurocognitive testing every 12 months, and biosamples collection at baseline are planned. Disease severity will be assessed every 6 months and history of environmental exposures will be assessed at baseline. Results: 33/75 expected patients with PSP (19) and CBS (14) have been enrolled. Female gender is 56%, mean age 76, with estimated disease duration of 4.73 years. More than 60% of enrolled patients have completed first visit and biosamples collection, one patient underwent brain donation, pathological diagnosis of PSP, clinical Richardson syndrome. Environmental exposures of a preliminary subsample are reported. Conclusions: The CAITauP enrolled a cohort of Argentinean PwPSP for deep clinical phenotyping and biobanking. Despite the rarity of PSP/CBS, we highlight the feasibility of establishing local cohorts in developing countries for translational research. The consortium aims to address underrepresented groups of Argentinean to improve diagnosis, treatment, and to create trial-ready cohorts.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".