Iodine-125 plesiotherapy for murine tumor treatment
Bibliographic record
Abstract
BACKGROUND: Radiotherapy (RT) is one of the four pillars of cancer treatment. Plesiotherapy, or contact brachytherapy, involves irradiating a tumor by placing small radioactive sources directly on the skin's surface above the tumor. In this study, we evaluated the efficacy of a novel local external radiation technique using iodine-125 seeds enclosed within a 3D-printed case, positioned externally on the tumor surface. METHODS: First, the protocol was tested on the skin of NodRag1 mice with doses up to 10 Gy (at the skin), and the results demonstrated no signs of skin toxicity. Subsequently, this protocol was used to locally irradiate subcutaneous MDA-MB-231 triple-negative breast cancer and MCA-205 fibrosarcoma tumors via a single 10 Gy dose at the tumor center. RESULTS: RT significantly hindered tumor growth, with irradiated tumors being approximately half the size of nonirradiated tumors on the same day. Importantly, the irradiated mice exhibited no apparent systemic side effects, as evidenced by stable body weight and unaffected behavior, including alertness, appearance, and activity levels. Moreover, no instances of skin toxicity were observed. CONCLUSIONS: This in vivo plesiotherapy protocol offers a straightforward and cost-effective means of advancing research on RT in a variety of laboratory settings.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".