0795 Novel Oral Appliance Therapy with Positive Expiratory Pressure Valve Successfully Treated Patients with Severe Obstructive Sleep Apnea (OSA)
Bibliographic record
Abstract
Abstract Introduction Oral Appliances (OA) are a primary therapy option for mild to moderate OSA patients and for severe OSA patients who are continuous positive airway pressure (CPAP) intolerant. However, there is a paucity of published data for efficacy of OA in severe OSA. A novel oral appliance, O2Vent Optima incorporates both the mandibular advancement and an air channel that allows airflow through the device to circumvent nasopharyngeal obstruction. The ExVent is an accessory to the mandibular advancement device and provides oral Expiratory Positive Airway Pressure (EPAP). Previous studies have established efficacy of the air channel and EPAP of the combination therapy in the treatment of mild to moderate OSA. The study purpose was to assess the efficacy of the EPAP enhanced novel OA in the treatment of severe OSA patients who were either CPAP intolerant or preferred other therapies. Methods A prospective, open-label study included 17 patients with severe OSA (AHI>30/hr.). Average age: 54.6±5.8 years; mean BMI: 32.6±4.3; 70% were men. Severe patients who were CPAP intolerant or preferred OA were approached for study participation and informed consented was obtained. The enrolled patients were evaluated, custom fitted with the EPAP enhanced novel OA and followed by the sleep dentists. Anterior adjustments of the of the OA was clinically guided and optimized, highest resistance EPAP valves (7 cmH2O) were utilized. T Primary Efficacy Measure: Change in AHI between baseline vs. EPAP enhanced OA. Secondary Efficacy Measures: Treatment success (percentage of patients with a ≥50% decrease in AHI from baseline); improvement in lowest oxygenation saturation (SpO2 nadir). Results Treatment with the EPAP enhanced OA reduced AHI from 41.4±11.23/hr. to 12.1±2.45/hr. (p< 0.005), average 71% reduction in AHI. The lowest oxygen saturation (SpO2 nadir) during sleep increased from 81.8±6.2% to 89.4±1.2% (p< 0.005). Treatment success rate was 86%. Conclusion Oral Appliance therapy offers an alternative treatment solution for patients with severe obstructive sleep apnea who are intolerant or refuse CPAP therapy; however, the data is limited. Our study demonstrated successful treatment of patients with severe obstructive sleep apnea with the novel EPAP enhanced Oral Appliance. Support (if any) Supported by a grant from Centre for Sleep and Chronobiology, Toronto, Canada.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".