CLINICAL SIGNIFICANCE OF INTERFERON STATUS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: PRELIMINARY DATA
Bibliographic record
Abstract
PV196 / #120 Poster Topic: AS22 - SLE Heterogeneity Background/Purpose Studies of systemic lupus erythematosus (SLE) pathogenesis have identified 2 major families of mediators: type I interferon (IFN-I) and autoantibodies to nucleic acids and their proteins, as the main factors contributing to the development of the disease. Against a background of genetic predisposition, a trigger stimulus, possibly microbial, induces the production of IFN-I, autoantibodies or, more likely, both, leading to inflammation. The interaction of cells of the innate and adaptive immune system are involved in the autoimmune response with the development of a variety of clinical manifestations of SLE. The aim of our study was to describe clinical and immunological characteristics of SLE depending on IFN gene signature (IFNGS). Methods This observational retrospective-prospective study included 76 patients (86% women, median aged 33 [25;43] years (median [interquartile range 25;75%]), with a definite diagnosis of SLE (SLICC 2012) attending a routine visit at our Clinic between February 2021 and June 2024. Baseline demographics, disease characteristic, organ system involvement/damage were analyzed descriptively according to SLE Disease Activity Index-2000 (SLEDAI-2K), Systemic Lupus International Collaborating Clinics damage index (SDI) and IFNGS status (high/low). IFN status was assessed by the expression of IFN-inducible genes (MX1, RSAD2, EPSTI1) using real-time polymerase chain reaction. IFNGS was calculated as the average expression value of 3 selected genes. In patients, IFNGS was considered high when the average value of gene expression exceeded the average value of gene expression in donors. The control group consisted of 20 healthy donors comparable in sex and age with the SLE patients. Results The median disease duration was 2.3 [0.2;11.0] years, SLEDAI-2K 7 [4;11], SDI 0 [0;2] score. IFNGS-high was detected in 72% of SLE patients. IFNGS-high patients were younger at the time of inclusion (31 [25; 41] and 40 [32; 49] years), had less frequent remission of SLE (SLEDAI-2K=0) (2% and 19%), and higher concentrations of anti-dsDNA (219.8 [120.3; 729.3] and 131.0 [46.6; 265.9] IU/ml, normal <100 IU/ml), ANF titer ≥1/1280 (84% and 52%), lower absolute count of blood leukocytes (4.2 [3.2; 5.6] and 6.6 [4.2; 8.8] х109/L) and lymphocytes (1.3 [0.8; 1.8] and 2.0 [1.2; 3.2] х109/L), p<0,05 in all cases. Of the criterion and non-criteria manifestations of SLE the greater proportions of IFNGS-high vs IFNGS-low patients had hematological (56% and 29%), primarily leukopenia (53% and 24%) and dermal (31% and 19%) involvement, p<0,05 in all cases. Conclusions Elevated type I IFN signaling is a marker of a certain type of SLE patients - young age with predominant skin, hematological and immunological disorders.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".