CLINICAL, LABORATORY CHARACTERISTICS AND OUTCOMES OF NEUROPSYCHIATRIC LUPUS ATTENDED IN LUPUS CLINICS: A PROSPECTIVE STUDY
Bibliographic record
Abstract
PV045 / #321 Poster Topic: AS05 - CNS Lupus Background/Purpose About half of SLE patients have neuropsychiatric symptoms at some point, although it’s rare as an initial presentation. Early diagnosis and treatment may lead to early remission and lower mortality. Present study aims to describe clinical and laboratory characteristics and outcomes of neuropsychiatric lupus Methods This is a prospective study ongoing at the lupus clinics of the National Institute of Neurosciences and Hospital and Popular Medical College Hospital in Dhaka. The study included all cases of SLE presenting with neuropsychiatric symptoms as per the ACR/EULAR nomenclature of CNS lupus and the 2019 classification criteria for SLE. The SLE DAI 2K scoring system was used to determine the disease activity. Standard treatments were administered, and patients are regularly following up in the respective sites. Outcomes are assessed in terms of remission, treatment failure, and death. Results In this study, a total of 32 patients were enrolled with a mean age of 24 and a male-female ratio of 1:8. The most common presentations were migrainous headache 19 (60%), convulsion 12 (38%), hemiparesis 5 (20%), and psychosis 5 (20%). The most prevalent neuroimaging characteristics of the brain were micro-hemorrhages 8 (38%), hemorrhagic infarct 7 (28%), and ischemic infarct 5 (20%). Additionally, the MR angiogram (MRA) of the cerebral artery revealed a beaded appearance in the middle cerebral artery (MCA) or its branches 9 (36%). MR venogram showed a filling defect, narrowing, and irregularity of the superior sagittal and transverse sinuses 5 (20%). Upon admission, the mean SLE DAI was 24 (± 9). After receiving standard treatment, complete remission occurred in 24 (72%) and partial remission in 7 (28%), with a median SLE DAI of 2 [1-4.5] at a minimum follow-up of 120 days. However, 1 patient expired while on treatment. Conclusions Migrainous headaches, convulsions, stroke, and psychosis are important neuropsychiatric manifestations of SLE. MRA helps to confirm vasculitis. Patients generally have a satisfactory outcome with standard treatment at 4 months.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".