SEVERE HEMATOLOGICAL MANIFESTATIONS IN SLE: 2 CASES OF THROMBOTIC THROMBOCYTOPENIC PURPURA
Bibliographic record
Abstract
PV209 / #633 Poster Topic: AS23 - SLE-Diagnosis, Manifestations, & Outcomes Background/Purpose Thrombotic thrombocytopenic purpura (TTP) is a rare but life-threatening hematological complication of systemic lupus erythematosus (SLE). In our cohort of 229 SLE patients, TTP was observed in 0.87% of cases. This report presents the clinical course and management of these patients. Methods We reviewed the medical records of 2 patients diagnosed with TTP secondary to SLE. Both cases were characterized by microangiopathic hemolytic anemia, thrombocytopenia, and multiorgan involvement. Treatment protocols, outcomes, and therapeutic responses were analyzed. Results • Case 1: Treated with intravenous methylprednisolone boluses (IVMP), intravenous immunoglobulin (IVIG), rituximab, and 12 cycles of eculizumab. The patient achieved remission with resolution of hematological and organ involvement. • Case 2: Treated with IVMP boluses, IVIG, and rituximab, leading to normalization of blood parameters and recovery of organ function. Conclusions TTP in SLE was identified in 0.87% of our cohort. Prompt recognition and aggressive treatment with IVMP, IVIG, and rituximab proved effective, with eculizumab playing a crucial role in refractory cases. Multidisciplinary collaboration and individualized treatment strategies are essential to improve outcomes in this rare but severe complication.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".