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Record W4410513848 · doi:10.1016/j.vaccine.2025.127254

Neurological adverse events following COVID-19 vaccination among Canadians referred to the special immunization clinic network

2025· article· en· W4410513848 on OpenAlexafffundabout
Tiffany Fitzpatrick, Peter Yamoah, David Summerby-Murray, Juthaporn Cowan, Manish Sadarangani, Alissa Wright, Sara Belga, Cora Constantinescu, Alex Carignan, Athena McConnell, Karina A. Top

Bibliographic record

VenueVaccine · 2025
Typearticle
Languageen
FieldMedicine
TopicPeripheral Neuropathies and Disorders
Canadian institutionsUniversité de SherbrookeAlberta Children's HospitalUniversity of CalgaryUniversity of British ColumbiaDalhousie UniversityBC Children's HospitalOttawa HospitalUniversity of SaskatchewanUniversity of AlbertaUniversity of Ottawa
FundersInstitute of Infection and ImmunityFaculty of Medicine, Dalhousie UniversityCanadian Institutes of Health ResearchKillam TrustsDalhousie UniversityMichael Smith Health Research BCBC Children's HospitalPublic Health Agency of CanadaUniversity of Ottawa
KeywordsImmunizationVaccinationCoronavirus disease 2019 (COVID-19)MedicineAdverse effect2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)PandemicVirologyPediatricsImmunologyOutbreakImmune systemInternal medicineDiseaseInfectious disease (medical specialty)

Abstract

fetched live from OpenAlex

Neurological adverse events have been reported rarely following COVID-19 vaccination. This study describes the characteristics of adolescents and adults assessed in the Canadian Special Immunization Clinic (SIC) Network for neurological adverse events following immunization (AEFIs) and outcomes of revaccination. Among 60 participants enrolled from January 2021 to February 2023, paresthesia/anesthesia was the most common diagnosis (15/60; 25.0 %), followed by Bell's Palsy (6/60; 10.0 %). Twenty-eight percent (17/60) of participants were hospitalized for their AEFI. Revaccination was recommended to 32/46 (69.6 %) participants due for subsequent doses when assessed in the SIC. Twenty-three participants were revaccinated and 4/23 (17.4 %) had recurrent symptoms of the AEFI; three were milder than the first event and none required hospitalization. Revaccination was generally safe in selected patients after a neurological AEFI. Expert assessment of patients with neurological AEFIs may help to support further vaccination.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.203
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.017
GPT teacher head0.296
Teacher spread0.280 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes3
Has abstractyes

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