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Record W4410519626 · doi:10.1111/nmo.70076

Gas‐Related Symptoms in the General Population: Prevalence, Impact and Associated Factors in a Survey of the United States, the United Kingdom, and Mexico

2025· article· en· W4410519626 on OpenAlexaff
Olafur S. Palsson, Douglas A. Drossman, Boris Le Nevé, Laurent Quinquis, Rim Hassouna, Johannah Ruddy, Max J. Schmulson, Carolyn Morris, Shrikant I. Bangdiwala, Magnus Simrén

Bibliographic record

VenueNeurogastroenterology & Motility · 2025
Typearticle
Languageen
FieldMedicine
TopicGastrointestinal motility and disorders
Canadian institutionsImpactMcMaster UniversityPopulation Health Research Institute
FundersDanone Nutricia ResearchDanone
KeywordsMedicineSomatizationAnxietyDepression (economics)Quality of life (healthcare)PopulationDemographyBloatingIrritable bowel syndromeMental healthGerontologyPsychiatryAbdominal painEnvironmental healthInternal medicine

Abstract

fetched live from OpenAlex

INTRODUCTION: The daily prevalence, impact, and associated personal and health factors of gas-related gastrointestinal (GI) symptoms in the general population are poorly understood and were investigated in a multi-national sample in this study. METHODS: Adults (18+ years) were surveyed nationwide via the Internet in the United States (USA), the United Kingdom (UK), and Mexico. The survey included the Intestinal Gas Questionnaire (IGQ), Rome IV diagnostic questions, anxiety, depression, somatization, and Quality of Life (QoL) questionnaires, as well as healthcare use and medical history questions. RESULTS: Five thousand nine hundred and seventy-eight respondents completed the survey: 49.1% female; mean age 44.8 years. IGQ global scores (range 0-100) were higher in Mexico (26.0) than in the United States (14.5) and the United Kingdom (13.7), higher among individuals under age 50 than older people, and only in Mexico higher in females than males. Almost all survey respondents (89%) reported one or more of the 7 IGQ gas-related symptoms in the past 24 h, with prevalence ranging from 39% for bloating to 81% for flatulence. Higher IGQ global scores correlated with lower physical (r = -0.46) and mental (r = -0.33) QoL; higher life stress (r = 0.43), anxiety (r = 0.43) and depression (r = 0.44) scores; and more non-GI physical symptoms (r = 0.50). A greater gas-related symptom burden was also related to higher prevalence of other gastroduodenal and bowel symptoms and increased doctor visits. CONCLUSIONS: Nearly all adults experience some daily gas-related symptoms. A higher burden of these symptoms is robustly associated with impairment in general QoL, increased anxiety, depression, stress, other GI symptoms, and increased healthcare needs.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.013
Threshold uncertainty score0.985

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.024
GPT teacher head0.296
Teacher spread0.272 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations8
Published2025
Admission routes1
Has abstractyes

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