CARDIOPULMONARY AND NEUROCOGNITIVE FUNCTIONALITY OF HYPERTENSIVE PATIENTS AFTER SARS-COV-2 INFECTION
Bibliographic record
Abstract
Objective: Few data have been published regarding the holistic approach of post-Covid patients with history of hypertension, examining both physical and mental health. The purpose of our prospective study was to follow up cardiorespiratory and neurocognitive status of hypertensives after Sars-Cov-2 infection. Design and method: All patients with history of Covid19 infection and good functional status were assessed using cardiorespiratory test and standardized questionnaires (Frailty scale, Montreal Cognitive Assessment score, Functionality Capacity Test) by a comprehensive team of experts (cardiologists, psychiatrists and psychologists). Population was divided into two groups according to hypertension status. Results: Out of total population of 198 patients (51±15 years, 44.4% males, 6.6% history of coronary heart disease) with Sars-Cov-2 infection were assessed. Hypertensives had higher BMI (p<0.001) and BSA (p<0.001) and they were hospitalized in higher percentage (p<0.01). Analysis of cardiorespiratory parameters recorded lower values of oxygen consumption (VO2 (ml/kg/min)) both at peak (p<0.001) and during the 1st minute of recovery (p<0.006), of metabolic equivalents (METS) at peak, (p<0.001) and HR1st minute recovery (p< 0.001) comparing to normotensives. As expected, systolic blood pressure (mmHg) at rest (p: 0.002), at peak (p: 0.01) and during the 1st minute of recovery (p: 0.001) as well as Borg scale score for dyspnea (p:0.02) were significantly higher while the exercise duration was lower (p<0.001) in hypertensive subjects. Similarly, out of psychometric tests used, DASI METS (p:0.008) and Functionality (p:0.036)) were also affected. In a subgroup analysis of hospitalized patients, impaired values of oxygen consumption both at peak (p: 0.01) and during the 1st minute of recovery (p: 0.02) were also recorded. Finally, using linear regression analysis adjusted for age, gender, hypertension status and hospitalization, age (p: 0.001) proved to be independent predictive factor for VO2, VO2_AT and VO21st minute of recovery in hypertensive patients. Conclusions: To conclude, the current study highlighted the reduced ability to exercise and fragility of patients with a history of hypertension whereas age proved to be an independent negative predictor of functionality. Therefore, the need for a more comprehensive approach of post-covid patients rehabilitation is mandatory.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".