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Record W4410594717 · doi:10.1007/s10461-025-04769-w

Identifying Syndemic Factors and Their Effect on HIV Sexual Risk Behavior Among Gay, Bisexual and Other Men Who Have Sex with Men in Vancouver, Montreal and Toronto

2025· article· en· W4410594717 on OpenAlexafffundabout
Felipe Duailibe, Tian Shen, Wendy Zhang, David Moore, Mark Hull, Justin Barath, Carly Magee, Nathan J. Lachowsky, Trevor Hart, Joseph Cox, Daniel Grace, Gilles Lambert, Shayna Skakoon‐Sparling, Jody Jollimore, Milada Dvořáková, Aki M. Gormezano, Viviane D. Lima

Bibliographic record

VenueAIDS and Behavior · 2025
Typearticle
Languageen
FieldMedicine
TopicHIV, Drug Use, Sexual Risk
Canadian institutionsCanadian AIDS Treatment Information ExchangeInstitut National de Santé Publique du QuébecMcGill University Health CentreToronto Metropolitan UniversityUniversity of TorontoMcGill UniversityUniversity of VictoriaUniversity of GuelphUniversity of British ColumbiaAIDS Vancouver
FundersHealth CanadaCanadian Institutes of Health ResearchMinistry of Health, British ColumbiaPublic Health AgencyGenome British ColumbiaToronto Metropolitan UniversityMichael Smith Health Research BCPublic Health Agency of CanadaOntario HIV Treatment NetworkCanadian Foundation for AIDS Research
KeywordsSyndemicHealth psychologyMen who have sex with menPublic healthSexual behaviorHuman immunodeficiency virus (HIV)HomosexualityMale HomosexualityDemographyAnal sexPsychologyMedicineGender studiesSociologyDevelopmental psychologySyphilisVirology

Abstract

fetched live from OpenAlex

We set out to identify syndemic factors associated with HIV sexual risk behavior among HIV-negative gay, bisexual and other men who have sex with men (GBM), and examine associations between syndemic factors and HIV sexual risk behaviors using models of co-occurring epidemics. We used baseline data from 1571 sexually active GBM from the Engage Cohort study, recruited using respondent-driven sampling in Montreal, Toronto, and Vancouver. We explored associations between potential syndemic factors and HIV sexual risk behavior, and used oblique component analysis to reduce the number of variables. Path analysis and logistic regression with interaction terms were used to evaluate the association of syndemic factors with HIV sexual risk behavior. In the mediation model, childhood sexual abuse (CSA) was associated with HIV sexual risk behavior (total effect: c = 0.14, 95% CI 0.06-0.21). This effect was mediated by any intimate partner violence (IPV), transactional sex, polysubstance use, and sexual compulsivity. We observed a multiplicative interaction between CSA and transactional sex: GBM with a history of both had 14 times the odds of HIV sexual risk behavior (aOR of 14.0 95% CI 5.6-35.2) compared to those with neither. The appropriate application of a syndemic approach allowed a nuanced assessment of syndemic factor associations with HIV sexual risk behavior. IPV, transactional sex, sexual compulsivity, and polysubstance use mediated the effect of CSA on HIV sexual risk behavior. Additionally, we found a significant multiplicative interaction between CSA and transactional sex.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.087
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.026
GPT teacher head0.326
Teacher spread0.300 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes3
Has abstractyes

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