Early Cardiovascular Events in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation
Bibliographic record
Abstract
BACKGROUND: Allogeneic hematopoietic stem cell transplantation (HSCT) is associated with organ toxicities, including cardiovascular (CV) complications. Data on contemporary acute postallogeneic HSCT cardiac complications and their impact on survival are scant. OBJECTIVES: The aim of the study was to determine the incidence of early CV events following allogeneic HSCT and their effect on survival within the first 100 days. METHODS: We conducted a single-center retrospective cohort study of adult patients who underwent allogeneic HSCT between 2004 and 2022. CV outcomes were a composite of CV death, myocardial infarction, heart failure, arrhythmia, stroke, or transient ischemic attack in early (≤100 days) postallogeneic HSCT. RESULTS: The 100-day cumulative incidences of CV events in 852 patients (median age: 54 years; 58.57% male) was 5.55% (95% CI: 4.13%-7.26%). The most frequent cardiac event was atrial arrhythmia (cumulative incidence: 3.92% [95% CI: 2.84%-5.56%]), followed by heart failure (cumulative incidence: 2.07% [95% CI: 1.26%-3.24%]). Age (subhazard ratio [SHR] per year: 1.07; 95% CI: 1.03-1.13) and left ventricular ejection fraction <50% before transplant (SHR: 3.16; 95% CI: 1.43-6.98) were independently associated with increased risk of CV events. Nonfatal CV events during the first 100 days were independently associated with an increased hazard of nonrelapse mortality (SHR: 6.25; 95% CI: 2.83-13.79) and all-cause mortality (HR: 5.79; 95% CI: 2.87-11.68). CONCLUSIONS: Although CV events are relatively uncommon in the first 100 days in patients after allogeneic HSCT, the occurrence of CV events is associated with high nonrelapse and all-cause mortality rates. Close monitoring of patients who develop CV events is recommended.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".