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The associations of childhood adversities and mental disorders with suicidal thoughts and behaviors - Results from the World Mental Health International College Student Initiative

2025· article· en· W4410610456 on OpenAlexafffund
Philippe Mortier, Xue Yang, Yasmin Altwaijri, Jacob A. Holdcraft, Sue Lee, Nancy A. Sampson, Yesica Albor, Ahmad N. AlHadi, Jordi Alonso, Nouf Al-Saud, Claes Andersson, Lukoye Atwoli, Randy P. Auerbach, Caroline Ayuya Muaka, Patricia M Báez-Mansur, Laura Ballester, Jason Bantjes, Harald Baumeister, Marcus Bendtsen, Corina Benjet, Anne H. Berman, Ronny Bruffaerts, Paula Carrasco, Silver C N Chan, Irina Cohut, María Anabell Covarrubias Díaz Couder, Marcelo A. Crockett, Pim Cuijpers, Daniel David, Dong Dong, David Daniel Ebert, Jorge Gaete, Mireia Félez-Nóbrega, Carlos G. Forero, Margalida Gili, Raúl A. Gutiérrez–García, Josep María Haro, Penelope Hasking, Xanthe Hunt, Mathilde M. Husky, Florence Jaguga, Leontien Jansen, Álvaro I. Langer, Yan Liu, Scarlett Mac‐Ginty, Vania Martínez, Andre Mason, Muthoni Mathai, Margaret McLafferty, Andrea Miranda-Mendizábal, Elaine Murray, Catherine Mawia Musyoka, Siobhan O’Neill, Claudiu Papasteri, José A. Piqueras, Codruța Alina Popescu, Charlene Rapsey, Kealagh Robinson, Tíscar Rodríguez‐Jiménez, Damian Scarf, Oi Ling Siu, Dan J. Stein, Sascha Y. Struijs, Cristina Tomoiagă, Karla Patricia Valdés‐García, Shelby Vereecke, Daniel Vigo, Angel Y Wang, Samuel Yeung Shan Wong, Ronald C. Kessler

Bibliographic record

VenuePsychiatry Research · 2025
Typearticle
Languageen
FieldPsychology
TopicSuicide and Self-Harm Studies
Canadian institutionsUniversity of British Columbia
FundersOrtho-McNeil PharmaceuticalFeilman FoundationUnited Nations Environment ProgrammeInterregNational Institutes of HealthFogarty International CenterMinisterul Cercetării, Inovării şi DigitalizăriiKoning BoudewijnstichtingHealth CanadaNational Institute of Mental HealthDivision of Research Capacity DevelopmentDepartament de Salut, Generalitat de CatalunyaPfizer FoundationInstituto de Salud Carlos IIIKing Salman Center for Disability ResearchPan American Health OrganizationNational Institute for Health and Care ResearchVlaamse regeringAgència de Gestió d'Ajuts Universitaris i de RecercaNational Health and Medical Research CouncilSaudi Basic Industries CorporationVetenskapsrådetUnitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si InovariiEli Lilly and CompanyUniversity of British ColumbiaZonMwEuropean CommissionConsejo Nacional de Ciencia y TecnologíaMinisterio de Ciencia e InnovaciónAgencia Nacional de Investigación y DesarrolloGeneralitat de CatalunyaKing Abdulaziz City for Science and TechnologyU.S. Public Health ServiceNational Institute on Drug AbuseJohn D. and Catherine T. MacArthur FoundationMinistry of Health – Kingdom of Saudi ArabiaSuicide Prevention AustraliaWellcome TrustInstitut Universitaire de FranceKing Faisal Specialist Hospital and Research CentreMedical Research CouncilFundació la Marató de TV3South African Medical Research CouncilNational Institute of Mental Health and NeurosciencesPublic Health AgencyGlaxoSmithKlineBristol-Myers SquibbKing Saud UniversityPfizer
KeywordsMental healthPsychologyPsychiatryClinical psychology

Abstract

fetched live from OpenAlex

OBJECTIVE: To investigate the associations of demographic variables, childhood adversities (CAs), and mental disorders (MDx) with onset, transition, and persistence of suicidal thoughts and behaviors (STB) among first-year university students. METHOD: Poisson regression models within a discrete-time survival framework were constructed using web-based self-report survey data from 72,288 incoming university students across 18 countries (response rate=20.9%; median age=19 years, 57.9% female, 1.4% transgender, 21.0% non-heterosexual). These models examined the associations of four demographic variables, five CAs, and eight MDx with STB outcomes. RESULTS: Lifetime prevalence of suicidal ideation, plans, and attempts was 47.0%, 26.0%, and 9.6%, respectively; 12-month estimates were 30.6%, 14.0%, and 2.3%. In unadjusted analyses, associations were strongest between lifetime onset of suicidal ideation and CAs (RR range 4.4-7.0), particularly parental psychopathology (relative risk [RR]=7.0 [95% CI 6.5-7.7]), followed by MDx (RR range 1.3-3.0). Of the demographic subgroups, transgender students had highest risk of STB (lifetime ideation onset RR=2.4 [2.3-2.6]; ideation-to-attempt transition RR=1.5 [1.3-1.8]). In fully adjusted models, strongest predictors of lifetime ideation onset were emotional abuse (RR=2.1 [1.9-2.2]), major depressive disorder (RR=2.0 [1.9-2.1]), and bipolar disorder (RR=1.8 [1.6-2.0]). Ideation-to-attempt transition remained most strongly associated with panic disorder (RR=1.5 [1.3-1.7]), bipolar disorder (RR=1.4 [1.2-1.7]), and sexual abuse (RR=1.4 [1.2-1.7]). Most predictors were significantly but weakly associated with persistence of ideation and plan, while only physical abuse remained associated with repeated suicide attempts (RR=1.3 [1.0-1.8]). CONCLUSION: CAs and MDx are strong predictors of both onset of and transition within the STB spectrum, underscoring the importance of implementing early-life prevention interventions.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesScience and technology studies
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.139
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0010.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.039
GPT teacher head0.412
Teacher spread0.373 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations11
Published2025
Admission routes2
Has abstractyes

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