Short-Term Removal of Exercise Impairs Flow-Mediated Dilation Similarly in Older and Younger Adults
Bibliographic record
Abstract
Endothelial function is decreased following removal of exercise in young adults. However, whether older adults also experience the same reduction in endothelial function following removal of exercise is not known. The purpose of the study was to investigate the effects of 3 and 5 days of removal of exercise (NOEX3, NOEX5, respectively) on brachial and popliteal artery FMD in older (n=12, 63.8±2.2 years) and younger (n=12, 23.9±0.7 years) adults who habitually exercise. %FMD in both the brachial (Old- EX: 7.58 (6.89); NOEX3: 5.58 (7.26); NOEX5: 6.05 (10.43); Young- EX: 7.93 (13.13); NOEX3: 6.57 (12.61); NOEX5: 6.50 (10.74); p=0.029) and popliteal (Old- EX: 6.56 (8.11); NOEX3: 4.95 (8.52); NOEX5: 4.56 (9.56); Young- EX: 6.15 (8.38); NOEX3: 6.19 (6.72); NOEX5: 4.77 (6.58); p=0.013) arteries were reduced following NOEX compared to EX. Peak diameter in both the brachial (Old- EX: 4.02 (0.62); NOEX3: 3.94 (0.62); NOEX5: 3.97 (3.97); Young- EX: 4.40 (0.49); NOEX3: 4.31 (0.52); NOEX5: 4.28 (0.52); p<0.01) and popliteal (Old- EX 5.74 (1.25); NOEX3: 5.64 (1.28); NOEX5: 5.62 (1.32); Young- EX: 6.07 (0.94); NOEX3: 6.03 (0.87); NOEX5: 5.92 (0.90); p<0.01) arteries were reduced during NOEX compared to EX. No significant main effects of group or interaction of group by phase were observed for %FMD or peak diameter (p>0.05). Thus, short-term removal of exercise in older and younger adults reduced brachial and popliteal artery endothelial function. However, no difference in reduction was observed between groups.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".