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Record W4410793215 · doi:10.3389/froh.2025.1484364

Effects of pomegranate extract on preventing dental caries: a systematic review

2025· review· en· W4410793215 on OpenAlex
Niyousha Rafeie, Yasaman Salimi, Zahra Sadat Aghamir, Amirhesam Amini, Hamed Taheri, Sarvin Sadreddini, Fatemeh Kamali, Golnesa Akbarian, Nazanin Azizi, Mobina Bagherianlemraski, Maryam Valizadeh, Farnoosh Alimohammadi, Negar Sedighnia, Mohammad Sadegh Qadirifard, Mahdyieh Naziri

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueFrontiers in Oral Health · 2025
Typereview
Languageen
FieldNursing
TopicPomegranate: compositions and health benefits
Canadian institutionsMcMaster University
Fundersnot available
KeywordsDentistryMedicineTraditional medicine

Abstract

fetched live from OpenAlex

Background/purpose The present study aimed to evaluate the effect of pomegranate extract on the prevention of dental caries compared to standard care, placebo, and no intervention. Materials and methods A bibliographic search in four databases, including PubMed, Scopus, Google Scholar, and CENTRAL, yielded 291 studies until September 8, 2023. The search was performed among the studies written in English using the search terms “ Punica granatum ” AND (“dental caries” OR “ Streptococcus mutans ” OR “tooth demineralization”) After screening the titles/abstracts and full texts of these studies, 7 articles were chosen. Results In all 7 articles, pomegranate mouthwash was used as the intervention. In 5 studies, the control group used 0.2% chlorhexidine (CHX) mouthwash. Additionally, 4 articles reported a reduction in the mean Streptococcus mutans plaque count in both groups; however, better results were observed in the CHX mouthwash group. In one study, no significant difference was reported between the study and control groups. Finally, one study showed the significant superiority of a hydroalcoholic extract of pomegranate mouthwash over CHX mouthwash. Conclusion Overall, the results suggest that pomegranate extract mouthwash is highly effective in reducing caries-causing bacteria. No side effects were reported for pomegranate use in these studies. Systematic Review Registration https://osf.io/69gpc/

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Systematic review · Consensus signal: Systematic review
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.242
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0070.001
Bibliometrics0.0010.002
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.025
GPT teacher head0.377
Teacher spread0.352 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it