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Record W4410833938 · doi:10.1080/14659891.2025.2512519

Correlates of alexithymia and its relationship with Kratom ( <i>Mitragyna speciosa</i> ) use in a cohort of male methamphetamine users in Malaysia

2025· article· en· W4410833938 on OpenAlexaboutno aff
Yuting Yang, Christian P. Müller, Darshan Singh

Bibliographic record

VenueJournal of Substance Use · 2025
Typearticle
Languageen
FieldPharmacology, Toxicology and Pharmaceutics
TopicAlkaloids: synthesis and pharmacology
Canadian institutionsnot available
Fundersnot available
KeywordsMethamphetaminePsychologyCohortAlexithymiaClinical psychologyPsychiatryMedicineInternal medicine

Abstract

fetched live from OpenAlex

Background Alexithymia is a typical clinical manifestation of prolonged methamphetamine use and risk transdiagnostic factor for emotion-based psychiatric disorders. Kratom (Mitragyna speciosa) co-consumption is becoming prevalent among methamphetamine users in Southeast Asia. Given its therapeutic value in mitigating mood disorders, it was hypothesized that methamphetamine users self-manage alexithymia effects with kratom.Methods A total of 367 male methamphetamine users with and without kratom use history participated in this cross-sectional study. Validated scales encompassing the Malay version of the Kratom Dependence Scale (KDS), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Toronto Alexithymia Scale (TAS-20), and Visual Analogue Scale (VAS) were administered.Results The level of alexithymia in methamphetamine users with kratom use history did not differ significantly from methamphetamine users without kratom use history. Similarly, among methamphetamine users with kratom use history, their alexithymia level did not contrast significantly across groups based on their duration (short vs. long-term) of methamphetamine and kratom use history. Indeed, only current age, age of first illicit drug use history, and anxiety were predictors for alexithymia level in methamphetamine users with kratom use history.Conclusions Kratom consumption cannot significantly predict alexithymia level. Its regular use did not appear to alleviate alexithymia in methamphetamine users.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.796

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.001
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.083
GPT teacher head0.362
Teacher spread0.279 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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