Multigenerational effects of temperature exposure on upper thermal limit and mitochondrial functioning in medaka (Oryzias latipes) brain
Bibliographic record
Abstract
Determining the mechanisms underpinning the thermal limits of organisms is essential to anticipate the impact of climate change on their survival. As mitochondrial activity is key for cellular ATP production, we aimed at investigating the link between mitochondrial dysfunction and the upper thermal limit (CT max ) at which neuromuscular functions are lost. We reared medaka fish (O ryzias latipes) over generations at 20°C (COLD) and 30°C (WARM) during five years and measured their CT max and their mitochondrial oxygen consumption rates (OCRs) at 25°C and at their CT max . We found that multigenerational exposure at elevated temperature increases the CT max by 13%. We observed for all fish a general decrease in the OCRs and for the RCR of complex-I between 25°C and their CT max suggesting a link between CT max and cerebral mitochondrial performance. Finally, we found an increase in the contribution of the mitochondria complex II to OCRs at elevated temperature suggesting that this complex underlie flexibility in mitochondrial functioning at high temperature. Our study highlights the link between whole organism thermal tolerance and mitochondrial dysfunction and that multigenerational exposure can modify mitochondrial and thermal performance.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".