Development and validation of an innovative HPLC-UV method for determination of Metalaxyl-M in flowable suspension fungicide formulas
Bibliographic record
Abstract
Metalaxyl-M is a modern and more efficient version of metalaxyl which is designated to provide effective control of damaging fungal diseases. This work aimed to develop and validate a low-cost, accurate, fast, and simple analytical method for determination of active ingredient metalaxyl-M using high-performance liquid chromatography with ultraviolet detection (HPLC-UV). The development of the novel method was performed on reversed-phase brownlee™ C-18 column at constant temperature 30 ºC. The mobile phase consists of acetonitrile and distilled water in volumetric ratio 62.5:37.5, a flow rate of 1.2 mL/min, and the detective wavelength at 270 nm. The validation protocol underscore in our study was SANCO/3030/99 rev. 5. Specificity, linearity, LOD, LOQ, precision, recovery, and accuracy parameters were calculated and discussed. The values for multiple correlation coefficient (R2 ≥ 0.990), relative standard deviation (RSD < 1.5 %), recoveries ranged from (99.21 - 101.16 %) were found within acceptance criteria.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".