Development and validation of an innovative HPLC-UV method for determination of Metalaxyl-M in flowable suspension fungicide formulas
Bibliographic record
Abstract
Metalaxyl-M is a modern and more efficient version of metalaxyl which is designated to provide effective control of damaging fungal diseases. This work aimed to develop and validate a low-cost, accurate, fast, and simple analytical method for determination of active ingredient metalaxyl-M using high-performance liquid chromatography with ultraviolet detection (HPLC-UV). The development of the novel method was performed on reversed-phase brownlee™ C-18 column at constant temperature 30 ºC. The mobile phase consists of acetonitrile and distilled water in volumetric ratio 62.5:37.5, a flow rate of 1.2 mL/min, and the detective wavelength at 270 nm. The validation protocol underscore in our study was SANCO/3030/99 rev. 5. Specificity, linearity, LOD, LOQ, precision, recovery, and accuracy parameters were calculated and discussed. The values for multiple correlation coefficient (R2 ≥ 0.990), relative standard deviation (RSD < 1.5 %), recoveries ranged from (99.21 - 101.16 %) were found within acceptance criteria.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".