Does cognition influence the perioperative trajectory of health-related quality of life? A longitudinal prospective cohort study
Bibliographic record
Abstract
BACKGROUND: Further characterization is needed to capture the trajectory of health-related quality of life in older surgical populations with cognitive impairment. This study aimed to (1) compare the perioperative trajectory of health-related quality of life between older noncardiac surgical patients with and without cognitive impairment; (2) assess preoperative health-related quality of life values associated with adverse clinical outcomes; and (3) explore preoperative factors associated with poorer health-related quality of life over time. METHODS: Health-related quality of life was assessed online using the EuroQol 5-Dimension 5-Level questionnaire preoperatively and postoperatively at 30, 90, and 180 days. A greater score indicated greater health-related quality of life. Cognition was assessed preoperatively using the Ascertain Dementia Eight-item Questionnaire and the Telephone Montreal Cognitive Assessment. Participants identified as having probable cognitive impairment were referred to as having cognitive impairment. RESULTS: EuroQol 5-Dimension 5-Level questionnaire scores significantly improved within 30 days postoperatively (0.718 ± 0.012 vs 0.690 ± 0.011, P = .04), with sustained gains at 90 (0.784 ± 0.013 vs 0.690 ± 0.011, P ≤ .001) and 180 days (0.797 ± 0.013 vs 0.690 ± 0.011, P ≤ .001). Although participants with cognitive impairment on the Ascertain Dementia Eight-item Questionnaire and those undergoing orthopedic surgery reported poorer health-related quality of life than their counterparts, they exhibited a greater rate of improvement over time. Lower education level, higher pain level, functional disability, depression, and having orthopedic surgery were associated with poorer health-related quality of life across all time points. Poorer preoperative health-related quality of life was associated with a higher incidence of delirium and non-home discharge. CONCLUSION: Health-related quality of life improves by 30 days postoperatively, with a greater rate of improvement among those with cognitive impairment on the Ascertain Dementia Eight-item Questionnaire and those undergoing orthopedic surgery.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.016 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".