Associations between the meniscal lesion parameters and knee joint structures and symptoms in patients with symptomatic knee osteoarthritis
Bibliographic record
Abstract
BACKGROUND: To investigate cross-sectional associations between meniscal lesion parameters and knee joint structures and symptoms in patients with symptomatic knee osteoarthritis (KOA). METHODS: A total of 102 subjects with symptomatic KOA were included in this study. Coronal magnetic resonance imaging was used to measure the meniscal parameters including the mean distance from medial to lateral meniscal lesions (Mean(MLD)), the mean value of tibial plateau width (Mean(TPW)) and the mean of the relative percentage of the medial to lateral meniscal lesions distance (Mean(RMLD)). The knee structural abnormalities and symptoms included Kellgren-Lawrence grade (KLG), cartilage volume, cartilage defects, bone marrow lesions (BMLs), joint space narrowing (JSN), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), pain, stiffness and physical dysfunction. RESULTS: In multivariate analyses, Mean(MLD) and Mean(RMLD) were significantly associated with KLG and were more efficient than cartilage volume and WOMAC in indicating the presence of KOA. The Mean(MLD) was significantly and negatively associated with total cartilage volume [β, 95%CI: -0.008(-0.012, -0.003)], medial tibial joint (MT) cartilage volume [β, 95%CI: -0.012(-0.017, -0.007)] and lateral tibial (LT) cartilage volume [β, 95%CI: -0.006(-0.011, -0.001)], and had positively associations with lateral tibiofemoral joint (LTFJ) cartilage defects, medial tibiofemoral joint (MTFJ) cartilage defects, LTFJ BMLs, and MTFJ BMLs [ORs, 95%CI: 1.063–1.116(1.007–1.059 to 1.119–1.177)] in patients with symptomatic KOA. There were positively associations between Mean(MLD) and WOMAC score [β, 95%CI: 2.145(1.160, 3.131)] in patients with KOA. Furthermore, The Mean(RMLD) was significantly and negatively associated with total cartilage volume [β, 95%CI: -0.005(-0.008, -0.002)], MT cartilage volume [β, 95%CI: -0.008(-0.011, -0.004)] and LT cartilage volume [β, 95%CI: -0.005(-0.008, -0.001)] and had significantly and positively associations with LTFJ cartilage defects, MTFJ cartilage defects, LTFJ BMLs, and MTFJ BMLs [ORs, 95%CI: 1.046–1.086(1.008–1.044 to 1.082–1.123)] in patients with symptomatic KOA. There were positively associations between Mean(RMLD) and WOMAC score [β, 95%CI: 1.465(0.793, 2.136)] in patients with KOA. CONCLUSIONS: Meniscus lesion parameter values were associated with changes in knee structures and increases in knee symptoms, suggesting that meniscal lesions may contribute to symptoms and structural abnormalities in the knee and increase the risk of KOA.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".