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Record W4410974580 · doi:10.1002/wnan.70020

Advancing Medical Applications of Cancer Nanotechnology: Highlighting Two Decades of the <scp>NCI</scp>'S Nanotechnology Characterization Laboratory Service to the Research Community

2025· review· en· W4410974580 on OpenAlexafffund
Rachael M. Crist, Yechezkel Barenholz, Ahuva Cern, Kate Clark, Pieter R. Cullis, Cheryl A. Dean, Neil Desai, Mauro Ferrari, Matthieu Germain, Carman A. Giacomantonio, Emma Grabarnik, Piotr Grodzinski, Atara Hod, Barry E. Kennedy, Ruvanthi N. Kularatne, Glen S. Kwon, Erin B. Noftall, L Pagliaro, Morteza Rasoulianboroujeni, Alexander M. Roth, Darren Rowles, Nicole F. Steinmetz, Zhanna Yehtina, Yao Zhang, Daniel Zilbersheid, Jeffrey D. Clogston, Stęphan T. Stern, Marina A. Dobrovolskaia

Bibliographic record

VenueWiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · 2025
Typereview
Languageen
FieldMaterials Science
TopicNanoparticle-Based Drug Delivery
Canadian institutionsUniversity of British ColumbiaCanada's Michael Smith Genome Sciences CentreDalhousie University
FundersCanadian Institutes of Health ResearchJames N. Kirby FoundationFrederick National Laboratory for Cancer ResearchNational Cancer InstituteNational Institutes of HealthU.S. Department of Health and Human ServicesF. M. Kirby FoundationU.S. Department of Defense
KeywordsNanotechnologyApplications of nanotechnologyService (business)EngineeringMaterials scienceBusiness

Abstract

fetched live from OpenAlex

The Nanotechnology Characterization Laboratory (NCL) is a US federally funded resource providing characterization and expertise to the cancer nanomedicine research community. Founded as a formal partnership among the US National Cancer Institute (NCI), the US Food and Drug Administration (FDA), and the US National Institute of Standards and Technology (NIST), the NCL has spent two decades developing a one-of-a-kind service with broad multidisciplinary expertise to meet the needs of a rapidly evolving drug development field. To mark the 20th anniversary of the lab's founding, the NCL hosted a symposium to highlight the achievements of the cancer nanomedicine field, showcase novel, next-generation nanotechnology research, and discuss future priorities to enable continued growth in combating cancer and the complexities associated with treating a disease that continues to take millions of lives annually. The discussion topics from this event are summarized.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.004
Threshold uncertainty score0.014

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.002
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0030.003
Science and technology studies0.0010.001
Scholarly communication0.0020.003
Open science0.0010.002
Research integrity0.0020.003
Insufficient payload (model declined to judge)0.0040.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.032
GPT teacher head0.383
Teacher spread0.351 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2025
Admission routes2
Has abstractyes

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Same venueWiley Interdisciplinary Reviews Nanomedicine and NanobiotechnologySame topicNanoparticle-Based Drug DeliveryFrench-language works237,207