Loss of <scp>NFIA</scp> Impairs Adult Hippocampal Neurogenesis
Bibliographic record
Abstract
Adult hippocampal neurogenesis (AHN) is the process by which new neurons are continuously generated from neural stem and progenitor cells (NSPCs) in the adult dentate gyrus. AHN plays a pivotal role in cognitive functions, including learning, memory, and mood regulation. Transcription factors regulate AHN by maintaining the NSPC pool and facilitating lineage progression. The nuclear factor I (NFI) transcription factor family member NFIA is critical for neurogenesis and gliogenesis during early brain development, but its role in adult neurogenesis remains poorly understood. Here, we generated an inducible Nfia loss-of-function mouse model to investigate the role of NFIA in Ascl1-lineage adult-born neurons. By tracking lineage progression from NSPCs to mature neurons, we found that NFIA deletion significantly reduced neurogenesis. Populations of NSPCs, neuroblasts, and mature granule neurons were all similarly diminished, indicating a primary defect in NSPC maintenance. Behaviorally, NFIA loss impaired hippocampal-dependent contextual fear memory without affecting locomotor activity, anxiety levels, spatial memory, or cued fear memory. Our findings demonstrate that NFIA is crucial for AHN and hippocampus-dependent contextual memory, thereby providing insights into its role in adult neurogenesis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".