Pharmacokinetics of nikkomycin Z following multiple doses in healthy subjects
Bibliographic record
Abstract
spp. The purpose of this study was to determine the pharmacokinetics and safety when administered as multiple, ascending doses in healthy subjects. Healthy adult volunteers received nikkomycin Z in oral doses ranging from 250 mg twice daily to 750 mg three times a day for 14 days. An intensive pharmacokinetic study was conducted after the first dose (day 1) and after the last dose (day 14). Subjects were also monitored for safety and tolerance but were not confined to the facility continuously. Doses were tracked by self-reporting and were observed prior to intensive pharmacokinetic studies. On day 14, the mean (sd) maximal concentration ranged from 3.70 (1.08) to 6.89 (1.59) mg/L, and mean time of maximal concentration ranged from 2.3 to 3.0 h. The mean area under the time curve from time 0 to end of the dosing interval (8 or 12 h) was 17.3 (5.2) mg h/L for 250 mg twice daily, 28.5 (9.5) for 500 mg twice daily, 34.5 (10.9) for 750 mg twice daily, and 35.6 (8.4) for 750 mg thrice daily. The mean half-life ranged from 1.94 to 2.18 h. Bioavailability was less than proportional to dose for the 750 mg doses. Nikkomycin Z was well tolerated, and the study was completed without any serious safety concerns. This study supports continued development of nikkomycin Z as a potential therapeutic for the treatment of coccidioidomycosis.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".