Bibliographic record
Abstract
Introduction:The Optilume BPH catheter system is a minimally invasive drug/ device combination therapy designed to treat lower urinary tract symptoms (LUTS) associated with benign prostatic enlargement (BPE).In this study, we assessed the outcomes related to maximum urinary flow rate (Qmax), quality of life (QoL), postvoid residual (PVR), and responses to a validated questionnaire.Methods: This prospective, single-arm, multicenter, open-label study was conducted across five Canadian centers to assess the effectiveness of the Optilume BPH system for treating LUTS caused by BPE.Functional and sexual outcomes were assessed in 30 catheter-free patients at baseline, on the treatment day, and at followup intervals of baseline, three, six, and 12 months.Results: Thirty patients underwent treatment for symptomatic BPE with the Optilume BPH system from July 2022 to August 2024.The average age was 63.06±2.5 years and mean prostate volume was 45.95 cc (IQR 33.72-63.1).The median baseline maximum urinary flow rate (Qmax) was 7.95 mL/s (IQR 5.87-11.25),and the median PVR was 77.5 mL (IQR 28.5-159.25 mL).The median duration of catheter use after the procedure was two days, with a range of 1-6 days.Thus far, 23 patients (54%) have completed the three-month followup, 17 patients the six-month followup, and seven patients the 12-month followup.At three, six, and 12 months, a marked increase in Qmax was observed, rising from a baseline of 8.74 to 15.8, 16.42, and 15.18 mL/s, respectively, suggesting sustained improvements in urinary function.Similarly, the PVR volume decreased substantially from a baseline of 94.54 mL to 66.82 mL at three months, and remained consistently lower at 68.14 mL at 12 months.Patient-reported symptom severity, measured by IPSS, showed a considerable reduction from 23.43 at baseline to 12.26 at three months and further improvement to 10.58 at six months, and 11.42 at 12 months.Sexual function, as assessed by the MSHQ-EJD and IIEF, displayed more stable trends.The MSHQ-EJD scores improved slightly from 1.89 to 2 at three months, stabilizing at around 1.71 at 12 months.The IIEF scores remained relatively consistent from 43.73 at baseline to 47.52 at three and six months, and 39.71 at 12 months.Conclusions: Over 12 months, patients showed a significant, sustained improvement in Qmax and a PVR.The IPSS also significantly decreased, demonstrating effective symptom relief.Sexual function remained stable with minor fluctuations, indicating that urinary improvements were achieved without compromising sexual health over the followup period.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.271 | 0.080 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".