MétaCan
Menu
Back to cohort
Record W4411178910 · doi:10.1038/s41390-025-04154-2

High-risk infant follow-up: current practice and factors determining eligibility

2025· article· en· W4411178910 on OpenAlexaff
Danielle Clifford, Sylke J. Steggerda, Nathalie L. Maitre, Linda S. de Vries, Deirdre M. Murray, Mariarita Capizzi, Julia Buchmayer, Jehier Afifi, Medha Goyal, Renato S. Procianoy, Hiroyuki Kidokoro, Sonika Agarwal, Rita C. Silveira, Jennifer Armstrong, André Graça, Samantha Sadoo, Jennifer C. Keene, Antti Juhani Kukka, Catarina Cordeiro, Andrea C. Pardo, Sonal Rakshpaul, Emma Butler, Laurel A. Slaughter, Nicholas William Nicoletti, Jessica Wickland, Nuria Boronat, Monique van de Lagemaat, Elisabetta Chiodin, Iyshwarya Stapleton, Tatiana Nuzum, Anna Tuiskula, Elise Roze, Anne Murray, Sophie Tremblay, Keimarisse Colón-Díaz, Srishti Jayakumar, Albertina Rego, Jennifer Check

Bibliographic record

VenuePediatric Research · 2025
Typearticle
Languageen
FieldMedicine
TopicNeonatal and fetal brain pathology
Canadian institutionsCentre Hospitalier Universitaire Sainte-JustineMcMaster Children's HospitalHospital for Sick ChildrenDalhousie University
FundersScience Foundation IrelandIrish Research eLibrary
KeywordsMedicineCurrent (fluid)PediatricsPhysics

Abstract

fetched live from OpenAlex

BACKGROUND: High-risk infant follow-up (HRIF) lacks universal definition. The aim of this study was to report current practice and factors used to identify eligibility for HRIF, yielding information which may provide a basis for future consensus. METHODS: A survey was prepared for a workshop at the 15th International Newborn Brain Conference on prediction of outcome, which was subsequently distributed to all attendees (n = 426). RESULTS: Follow-up was offered by 97% of respondents (n = 113/116). HRIF was offered to infants born <28 weeks by 47%, to those <32 weeks by two-thirds (66%) and to preterms based on neuroimaging by 54%. For infants born full-term, HRIF was offered by 88% in neonatal encephalopathy (NE) and 86% in neonatal stroke. HRIF continued most frequently until 24 months corrected (33.6%). For guiding prognosis in preterm infants, 22% (n = 25) selected neuroimaging as the most important factor. For NE, 54% (n = 63) selected neuroimaging findings as the most important factor in guiding prognosis and 14% (n = 16) selected EEG/aEEG. Social factors are not considered by 46% in determining HRIF eligibility. CONCLUSION: Significant variability in HRIF exists, without consensus. Awareness of factors predicting prognosis and the importance of social risk-factors must improve to allow accurate identification of those at highest risk. This information may act as a basis for future consensus on HRIF. IMPACT: There is no clear consensus on eligibility or duration of high-risk infant follow-up. We report current practice in, and factors used to identify eligibility for same, amongst attendees of the International Newborn Brain Conference. This information on international practice may provide a basis for future consensus. Given the importance of accurate prognostication in risk-stratification, we report participants' awareness of the most important factors guiding prognosis. A disconnect between the impact of social factors on outcome and their consideration for eligibility of high-risk infant follow-up is noted. We propose the need for guidelines on follow-up of socially disadvantaged, medically high-risk infants.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.011
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.110
Threshold uncertainty score0.997

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.011
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.053
GPT teacher head0.424
Teacher spread0.371 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations8
Published2025
Admission routes1
Has abstractyes

Explore more

Same venuePediatric ResearchSame topicNeonatal and fetal brain pathologyFrench-language works237,207