Current research progress of tranexamic acid in the management of patients with traumatic injuries in emergency settings
Bibliographic record
Abstract
Introduction The trauma is a leading cause of global mortality, with hemorrhage being a major contributor. Tranexamic acid (TXA), an antifibrinolytic agent, has shown promise in reducing blood loss and improving outcomes in trauma patients. Despite evidence from the CRASH-2 and CRASH-3 trials demonstrating its efficacy when administered within 3 h post-injury, tranexamic acid remains underutilized in clinical practice. This review aims to synthesize current evidence on TXA's efficacy, mechanisms, and clinical applications in the trauma management, identify research gaps, and propose future directions to optimize its use. Methods A comprehensive literature search was conducted using PubMed, Embase, and Cochrane Library up to April 2025. Search terms included “tranexamic acid,” “trauma,” “hemorrhage,” and “emergency medicine.” Included studies were randomized controlled trials (RCTs), systematic reviews, meta-analyses, or observational studies evaluating TXA's efficacy, safety, or mechanisms in trauma patients. Case reports, editorials, and non-English studies were excluded. Data extraction and quality assessment were performed independently by two reviewers using the Cochrane Risk of Bias Tool and Newcastle-Ottawa Scale. Results The review included 31 studies (15 RCTs, 10 systematic reviews, 6 observational studies). Early the TXA administration within 3 h post-injury significantly reduced mortality, with the CRASH-3 trial showing benefits within 8 h for traumatic brain injury. TXA inhibits plasminogen activation, stabilizing clot formation and reducing fibrinolysis, while also exhibiting anti-inflammatory properties. Intravenous TXA was more effective than oral administration. TXA reduced blood transfusions, reoperations, and blood loss in surgical settings. Limitations included variability in study designs, small sample sizes, and lack of long-term. Discussion The TXA is a critical intervention in the trauma management, reducing mortality and morbidity from hemorrhage. Early intravenous administration is preferred, and its anti-inflammatory properties may enhance recovery. However, underutilization in pre-hospital settings highlights the need for increased awareness and training. Future research should focus on individualized protocols, alternative administration routes, long-term safety, and combining TXA with other therapies to optimize trauma care. Conclusion The TXA is a valuable therapeutic option in the trauma management, with significant potential to improve outcomes. Addressing current limitations and exploring new research directions will be essential to maximize its clinical benefits.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".