Neurobiological Delusions: Regional Cerebral Blood Flow insights into Cotard’s Syndrome and Schizophrenia
Bibliographic record
Abstract
Cotard’s syndrome is a clinically rare condition that is characterized by nihilistic or immortality delusions, which are often accompanied by thoughts of suicide, depression, and anxiety. These symptoms vary among individuals but are generally distinguished as a neuropsychiatric disorder. The cause of this condition is further investigated in a recent case study, where a 52-year-old male patient diagnosed with schizophrenia and mild intellectual disability is examined. The patient suffered from several lumbar fractures due to an attempted suicide, and after admission to the hospital, the patient was diagnosed with Cotard’s syndrome. This study aimed to assess the longitudinal changes of regional cerebral blood flow (rCBF) on a single-photon emission computed tomography (SPECT) scan, with respect to a schizophrenic patient displaying Cotard’s syndrome. The symptoms of Cotard’s syndrome appear to dissipate through administration of Lurasidone, which is observed through SPECT and changes in rCBF. The observed correlation between the development of Cotard’s syndrome and an increased rCBF provides a strong basis on the nature of the condition, and enhanced understanding of neuropsychiatric conditions.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".