Participation of the TRPA1 Receptor in the Antinociceptive and Anti-Inflammatory Effect of the α, β-Amyrin Mixture in Adult Zebrafish (Danio rerio)
Bibliographic record
Abstract
Inflammatory pain is a symptom associated with different human diseases, and they are treated with drugs that have several serious side effects. The triterpene mixture of α, β-amyrin (ABAM) has already been reported with antinociceptive and anti-inflammatory effects in mice. The antinociceptive potential of ABAM possibly involves the mechanisms of opioid and vanilloid receptors. This study aimed to determine the antinociceptive and anti-inflammatory potential of ABAM in adult zebrafish by modulating TRPA1. Thus, ABAM had its antinociceptive effect investigated by the nociception model in adult zebrafish induced by formalin. Furthermore, the possible neuromodulation by the TRPA1 channel was evaluated by pre-treatment with camphor. ABAM exhibited significant antinociceptive and anti-inflammatory effects in adult zebrafish at all tested doses. These effects, potentially mediated through TRPA1 modulation, were observed without signs of toxicity over a 96-hour period.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".