Pharmacokinetics and behavioural effects of a single oral dose of trazodone in rabbits
Bibliographic record
Abstract
Objectives To evaluate the pharmacokinetics and pharmacodynamics of a single oral dose of trazodone in laboratory rabbits. Study design Randomized, blinded, Latin-square study. Animals Eight healthy, juvenile, female New Zealand White rabbits. Methods Auricular venous catheters were placed in six rabbits before oral trazodone (20 mg kg –1 ) administration. Blood was sampled immediately before and at 15 and 30 minutes, and 1, 2, 4, 8, 12, 18, and 24 hours after treatment. Trazodone plasma concentrations were determined using high-performance liquid chromatography-mass spectrometry. Eight rabbits were equipped with accelerometers (activity) and video recorded. They randomly received one of three treatments: oral trazodone (20 mg kg –1 ; TRAZ), placebo (corn oil base; PLAC), or no treatment (CONTR) with a 3-day washout period between treatments. Exploring, grooming, resting, vigilance, hiding and ingesting behaviours were evaluated for 10 hours (0–2, 2–4, 4–6, 6–8, and 8–10 hours). Results Mean maximum plasma concentration, 6,592.6 ± 586.5 ng mL –1 , was reached 0.3 ± 0.11 hours after treatment. Mean half-life was 3.24 ± 0.36 hours, and area under the curve from zero to infinity 25,412.5 ± 5,420.9 ng mL –1 hour –1 . Activity was higher in TRAZ and PLAC than CONTR at 0–2 hours with TRAZ exploring more. Hiding was reduced in TRAZ versus CONTR (0–2 hours and 4–6 hours), and versus PLAC (0–6 hours). Resting increased in TRAZ versus PLAC (2–4 hours) and CONTR (4–6 hours); PLAC rested less at 2–4 hours than at 8–10 hours. Vigilance tended to be lower in TRAZ versus CONTR. Food intake decreased in TRAZ at 2–4 hours. Grooming varied over time. Conclusion and clinical relevance Trazodone-treated animals showed reduced activity, less hiding, more resting compared to PLAC and decreased food intake 2–4 hours post-treatment.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".