MétaCan
Menu
Back to cohort
Record W4411489485 · doi:10.1039/d5nj00175g

Synthesis and biological studies on ovarian cancer cells of new heterocyclic molecules inspired by MIM1, an inhibitor of the anti-apoptotic protein Mcl-1

2025· article· en· W4411489485 on OpenAlexfundno aff
Jocelyn Pezeril, Louis‐Bastien Weiswald, Ali Soulieman, Hippolyte Paysant, Ali Hachem, Émilie Brotin, Christophe Denoyelle, Anne Sophie Voisin‐Chiret, Nicolas Gouault, René Grée, Nicolas Levoin, Laurent Poulain

Bibliographic record

VenueNew Journal of Chemistry · 2025
Typearticle
Languageen
FieldChemistry
TopicSynthesis and biological activity
Canadian institutionsnot available
FundersEuropean Social FundEuropean Regional Development FundRégion NormandieCentre National de la Recherche ScientifiqueLigue Contre le CancerUniversité LibanaiseConseil National de la Recherche ScientifiqueInstitut National de la Santé et de la Recherche MédicaleAgence Universitaire de la FrancophonieEuropean Commission
KeywordsChemistryApoptosisBioorganic chemistrySmall moleculeMoleculeCancerCancer researchCancer cellCombinatorial chemistryBiochemistryOrganic chemistryEnzymeInternal medicine

Abstract

fetched live from OpenAlex

Research on new and potent inhibitors of anti-apoptotic proteins is a very active and promising topic in bioorganic and medicinal chemistry.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.007
Threshold uncertainty score0.474

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.028
GPT teacher head0.272
Teacher spread0.244 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

Explore more

Same venueNew Journal of ChemistrySame topicSynthesis and biological activityFrench-language works237,207