Insulin resistance in non-diabetic premenopausal female patients with fibromyalgia: relation to disease characteristics
Bibliographic record
Abstract
Abstract Background Fibromyalgia syndrome (FMS) and insulin resistance (IR) may share common pathophysiological features. We aimed to investigate the role of IR among FMS patients and investigate its relation to various mutations in the catechol-O-methyltransferase (COMT) gene. Methods and results A case–control study which included 120 women (60 diagnosed as having FMS and 60 healthy women as a control group) aged from 22 to 40 years was conducted. Patients had significantly increased HbA1C% (5.49 ± 0.35) and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (1.74 ± 1.23) than controls (4.99 ± 0.27 and 0.92 ± 0.15, respectively) ( p < 0.001). The patients with the COMT A/A genotype had significantly higher mean values of the symptom severity score, painDETECT, McGill Pain, visual analog scale, Fibromyalgia Impact Questionnaire, and Small Fiber Neuropathy Screening List ( p = 0.004, 0.004, 0.013, 0.019, 0.005, and 0.001, respectively). Conclusion IR was significantly higher among FMS patients, and patients with the COMT A/A allele had greater pain sensitivity. Thus, IR may have an add-on effect on pain in FM.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".