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Record W4411674098 · doi:10.1016/j.mcpro.2025.101024

A Roadmap for Improving Reliability and Data Sharing in Crosslinking Mass Spectrometry

2025· article· en· W4411674098 on OpenAlexaff
Juri Rappsilber, James E. Bruce, Colin Combe, Stephen D. Fried, Andrea Graziadei, Albert J. R. Heck, Claudio Iacobucci, Alexander Leitner, Karl Mechtler, Petr Novák, Francis J. O’Reilly, David C. Schriemer, Andrea Sinz, Florian Stengel, Konstantinos Thalassinos

Bibliographic record

VenueMolecular & Cellular Proteomics · 2025
Typearticle
Languageen
FieldChemistry
TopicMass Spectrometry Techniques and Applications
Canadian institutionsUniversity of Calgary
FundersH2020 European Research CouncilDeutsche Forschungsgemeinschaft
KeywordsMass spectrometryReliability (semiconductor)ChemistryComputer scienceChromatographyPhysics

Abstract

fetched live from OpenAlex

OpenAlex records an abstract for this work, but it could not be fetched just now.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.369
metaresearch head score (Gemma)0.351
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesMetaresearch
DomainCandidate signal: Reproducibility · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.631
Threshold uncertainty score0.779

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.3690.351
Meta-epidemiology (narrow)0.0040.003
Meta-epidemiology (broad)0.0050.006
Bibliometrics0.0090.008
Science and technology studies0.0040.011
Scholarly communication0.0200.052
Open science0.0210.026
Research integrity0.0120.017
Insufficient payload (model declined to judge)0.0140.009

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.015
GPT teacher head0.284
Teacher spread0.268 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; the direct Gemma label and the distilled Codex classifier agree on what is shown here.

Study designNot applicable
DomainReproducibility
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2025
Admission routes1
Has abstractyes

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