A case report and literature review on a large MDM2 negative retroperitoneal/psoas muscle well-differentiated liposarcoma mimicking intramuscular myxoma
Bibliographic record
Abstract
Well-differentiated liposarcoma (WDLPS) typically presents as a large soft tissue mass in the retroperitoneal region. Amplification of the MDM2 gene is considered the gold standard for pathologic diagnosis. We present a case of 22 cm large intramuscular mass, located in the psoas muscle of the retroperitoneum. No macroscopic fat was identified on imaging, and the lesion featured extensive myxoid stroma, closely mimicking an intramuscular myxoma on both radiological and histopathological evaluation from biopsy sample. Final diagnosis was however revised to MDM2-negative WDLPS. This case highlights the diagnostic challenge posed by WDLPS with extensive myxoid stroma lacking MDM2 amplification and macroscopic fat on imaging. Accurate diagnosis relies on the integration of clinical, radiologic, and pathologic data, as well as thorough sampling of the tumor.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.006 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".