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Record W4411687292 · doi:10.1371/journal.pone.0325709

Characterizing the content and quality of internet resources on exercise training in Ehlers-Danlos Syndromes and generalized hypermobility spectrum disorder

2025· article· en· W4411687292 on OpenAlexafffund
Jillian Dhawan, Sahar Sohrabipour, Aymen Al-Timimi, Brenawen Elangeswaran, Omer Choudhary, Noor Al Kaabi, Megha Ibrahim Masthan, Daniel Santa Mina, Laura McGillis, Encarna Camacho Pérez, Jane R. Schubart, Mark E. Lavallee, Timothy Sheehan, Neyha Cherin, Nimish Mittal, Hance Clarke, Rebecca Bascom, Dmitry Rozenberg

Bibliographic record

VenuePLoS ONE · 2025
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicConnective tissue disorders research
Canadian institutionsToronto General HospitalUniversity of TorontoUniversity Health Network
FundersTemerty Faculty of Medicine, University of TorontoUniversity of TorontoEhlers-Danlos Society
KeywordsEhlers–Danlos syndromeReadabilityHypermobility (travel)MedicinePhysical therapyAthletic trainingPhysical medicine and rehabilitationSurgery

Abstract

fetched live from OpenAlex

BACKGROUND: Individuals with Ehlers-Danlos Syndromes (EDS) and Generalized Hypermobility Spectrum Disorder (G-HSD) experience musculoskeletal joint instability, cardiopulmonary manifestations, and functional limitations with online exercise resources commonly utilized. This study characterizes and assesses the content, quality, and readability of websites addressing exercise training for individuals with EDS/G-HSD. METHODS: The first 350 English websites were Googled using search terms "Ehlers-Danlos Syndrome and exercise" and "Ehlers-Danlos Syndrome and physical activity," targeting educational/instructional sites on exercise training for adults with EDS/G-HSD. Content was assessed using scientific consensus criteria, quality using Modified DISCERN, Global Quality Scale (GQS), and the Patient Education Materials Assessment Tool (PEMAT), and readability using Flesch-Kincaid Grade Level (FKGL) and Flesh-Reading Ease Scores (FRES). RESULTS: 78/350 unique websites were included, most from industry organizations (37%) and personal commentary (24%). The mean content score was moderate 13.8 ± 4.4/25. The content most discussed included: short/long-term benefits of muscle strength, resistance training, and generalized exercise safety considerations. Median modified DISCERN and GQS scores were 4/5 IQR [3-4] and 3/5[2.3-4], respectively. Mean PEMAT understandability and actionability scores were 85% ± 12% and 69% ± 23%, respectively. Average FKGL was 11.0 ± 2.7 and FRES was 43.6 ± 7.2. Moderate-strong Spearman correlations were observed between total content scores and GQS (rho = 0.76) and DISCERN (rho = 0.52), p < 0.001 for both. CONCLUSION: Website content varied, most addressing general safety recommendations and multiple training modalities. While quality was moderate-to-good, future resources should focus on simplified language, actionable guidance, and visual aids. Incorporating practical examples of daily activities, injury prevention strategies, broader benefits like cardiovascular health, and psychological support can empower safe and confident exercise training.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.024
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.006
Threshold uncertainty score0.017

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.024
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0060.003
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.121
GPT teacher head0.310
Teacher spread0.189 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

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