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Record W4411690318 · doi:10.1183/23120541.00089-2025

The safety, physiological response and repeatability of the incremental shuttle walk test in survivors of COVID-19

2025· article· en· W4411690318 on OpenAlexfundno aff
Molly M Baldwin, Enya Daynes, Urvee Karsanji, Hamish McAuley, Nicolette C. Bishop, Charlotte E. Bolton, William D‐C Man, Ioannis Vogiatzis, James D Chalmers, Ling‐Pei Ho, Alex Horsley, Michael Marks, Krisnah Poinasamy, Betty Raman, Olivia C. Leavy, Matthew Richardson, Omer Elneima, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Ruth Saunders, Victoria Harris, Linzy Houchen-Wolloff, Neil Greening, Ewen M Harrison, Annemarie B Docherty, Nazir Lone, Jennifer K Quint, Louise V. Wain, Christopher E Brightling, Rachael A Evans, Sally Singh

Bibliographic record

VenueERJ Open Research · 2025
Typearticle
Languageen
FieldMedicine
TopicLong-Term Effects of COVID-19
Canadian institutionsnot available
FundersNIHR Leicester Biomedical Research CentreMenzies Centre for Australian Studies, King's College London, University of LondonMedical Research CouncilManchester Biomedical Research CentreLiverpool University Hospitals NHS Foundation TrustBarts Health NHS TrustBlood Cancer UKSt George's University Hospitals NHS Foundation TrustNorth Bristol NHS TrustQueen's UniversityCambridge University HospitalsSwansea UniversityDeakin UniversityUniversity of NottinghamUniversity Hospitals of Leicester NHS TrustUniversity of BristolPublic Health EnglandQueen's University BelfastImperial College LondonDepartment of Health and Social CareUniversity of LeicesterKidney Research UKUniversity of CambridgeBritish Heart FoundationQueen Mary University of LondonNational Institute for Health and Care ResearchGenentechAstraZenecaInsmedSwansea Bay University Health BoardUniversity of LeedsHealth and Care Research WalesRoyal Free London NHS Foundation TrustLondon School of Hygiene and Tropical MedicineUniversity of GlasgowModernaStrongPfizerKing's College LondonNewcastle upon Tyne Hospitals NHS Foundation TrustCystic Fibrosis TrustGrifolsUniversity College LondonImperial College Healthcare NHS TrustDiabetes UKUniversity of SouthamptonAsthma and Lung UKNottingham University Hospitals NHS TrustKing's College Hospital NHS Foundation TrustOxford University Hospitals NHS Foundation TrustUniversity Hospital Southampton NHS Foundation TrustVersus ArthritisRegeneron PharmaceuticalsBetsi Cadwaladr University Health BoardUniversity of HullSouth London and Maudsley NHS Foundation TrustSanofiNHS Greater Glasgow and ClydeUK Research and InnovationUniversity of OxfordUniversity of WarwickBritish Lung FoundationUniversity of Dundee
KeywordsMedicineCoronavirus disease 2019 (COVID-19)Repeatability2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Test (biology)AeronauticsVirologyInternal medicineStatisticsDisease

Abstract

fetched live from OpenAlex

Background: The incremental shuttle walk test (ISWT) may be a valuable tool for measuring exercise tolerance in patients after a hospital admission with COVID-19. However, the safety, physiological response and repeatability of the ISWT are unknown in this cohort. The present study aimed to explore the properties of this test using the Post-Hospital COVID-19 (PHOSP-COVID) study. Methods: Participants performed two ISWTs, with a 30-min rest between tests, at 5 and 12 months post-hospital discharge for COVID-19. Heart rate and fingertip peripheral oxygen saturation were recorded pre- and post-test. Reasons for test termination were noted. Results: ; 967 (60.7%) males) performed an ISWT; two tests were performed by 1034 and 390 participants at the 5- and 12-month visit, respectively. At 5 months post-discharge, six patients (0.4%) had an adverse event and the most common reason contributing to test termination was breathlessness (826 (54.2%) participants). 336/1470 (22.9%) participants experienced exertional desaturation. Distance walked was greater in the second ISWT compared to the first ISWT at 5 and 12 months post-discharge (mean±sd difference: 5 months: 19±94 m; 12 months: 11±80 m; p<0.05), with an intraclass correlation coefficient estimate of 0.96 (95% CI 0.95-0.97) at 5 months and 0.97 (95% CI 0.96-0.97) at 12 months. Conclusions: The ISWT appeared to be safe in this large cohort, supporting use of this field walking test for this population in clinical and research settings. A familiarisation test is recommended, with further study needed to determine the number of familiarisation tests required to achieve acceptable within-day repeatability.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.019
metaresearch head score (Gemma)0.063
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.067
Threshold uncertainty score0.997

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0190.063
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.003
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.079
GPT teacher head0.456
Teacher spread0.377 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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