Gamma–Theta–Spike Coupling Coordinates Sequential Memory in Human MTL
Bibliographic record
Abstract
Abstract It has been suggested that hierarchical synchronization of theta and gamma oscillations coordinates neural activity during sequence memory. Yet, the role of gamma oscillations and their interaction with theta and single-unit activity (SUA) has not been directly examined in humans. We analysed simultaneous micro wire recordings of single-unit activity (N = 1417) and local field potentials (N = 917 channels) from the medial temporal lobe (MTL) of epilepsy patients performing a visual multi-item sequence memory task. During encoding, both spiking activity and gamma power contained item-specific information and were temporally coupled. During memory maintenance, stimulus-specific gamma was characterized by recurring bursts during which spiking was tightly synchronized and both, gamma and spiking, were preferentially aligned to similar theta phases predictive of sequential stimulus position. These findings demonstrate that theta–gamma–spike interactions support a phase-based multiplexed code for sequential memories in the human MTL.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.004 | 0.002 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".