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Record W4411790193 · doi:10.1162/imag.a.79

Open-source platforms to investigate analytical flexibility in neuroimaging

2025· article· en· W4411790193 on OpenAlexafffund
Jacob Sanz-Robinson, Michelle Wang, Brent McPherson, Yohan Chatelain, David W. Kennedy, Tristan Glatard, Jean‐Baptiste Poline

Bibliographic record

VenueImaging Neuroscience · 2025
Typearticle
Languageen
FieldNeuroscience
TopicFunctional Brain Connectivity Studies
Canadian institutionsCentre for Addiction and Mental HealthConcordia UniversityMcGill UniversityMontreal Neurological Institute and Hospital
FundersNational Institute of Mental HealthCanadian Institutes of Health ResearchNational Institutes of HealthHealth CanadaCanada First Research Excellence FundNational Institute of Biomedical Imaging and BioengineeringChan Zuckerberg InitiativeFondation Brain CanadaMcGill UniversityMichael J. Fox Foundation for Parkinson's Research
KeywordsComputer scienceFlexibility (engineering)Robustness (evolution)Data scienceNeuroimagingSoftwarePipeline (software)Software engineering

Abstract

fetched live from OpenAlex

Researchers in brain imaging have access to a multitude of analysis tools, many of which carry out the same or similar tasks but yield different results when applied to the same data. This analytical flexibility often undermines reproducibility and raises concerns about the robustness of neuroimaging studies. However, the array of software packages to investigate and address analytical flexibility is decentralized, scattered, and not well documented. Consequently, researchers often lack the necessary information and protocols to buttress the reliability of their findings across analytical tools. This review catalogs and describes software platforms (i.e., software or computational libraries) that can be used to address result variability arising from computational pipelines and environments and explores the use of computing platforms and neuroimaging pipeline frameworks in addressing this issue. This study offers guidance to the research community on accessing, understanding, and utilizing these platforms to address brain imaging analytical flexibility. Additionally, the article provides specific recommendations tailored to different user groups, considering the tools they intend to use with these platforms and their computational constraints.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.041
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.504
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.041
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.004
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0020.003
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.082
GPT teacher head0.354
Teacher spread0.272 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes2
Has abstractyes

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