Case Series of Six Patients with Inflammatory Myositis Seen at a Specialized Pregnancy and Rheumatic Diseases Clinic
Bibliographic record
Abstract
Background Dermatomyositis (DM) is a systemic autoimmune disease which can present with proximal muscle weakness, cutaneous eruptions, and interstitial lung disease. There is limited data on the impact of pregnancy on DM. A few studies have suggested increased rates of adverse pregnancy outcomes in this population, but this has not been firmly established. In this case series, we describe 6 pregnancies in women with DM who were followed at a specialized pregnancy and rheumatic diseases clinic (PReDICT). Case We used a prospective registry of patients seen at PReDICT and identified those with dermatomyositis or polymyositis between 2021-2024. Six patients with DM, who were managed at PReDICT throughout the 3 trimesters of pregnancies and 6 weeks postpartum, were included in the study. Five of the patients had a pre-existing diagnosis of DM prior to pregnancy. One patient presented with a new diagnosis of DM in the 1st trimester of pregnancy. Patients who had pre-pregnancy counseling had low disease activity at conception and conceived on pregnancy-compatible medications. One patient (Patient 2) experienced a possible flare during pregnancy during the 2nd trimester, manifesting as dyspnea, hoarseness of voice, and dysphagia, and requiring an increase in dose of prednisone from 5 mg to 10 mg. One patient (Patient 3) experienced a postpartum flare involving both the skin and muscles which required initiation of Tacrolimus and IVIG. All other patients remained in remission (Patients 1 and 5) or stable low disease activity (Patients 4 and 6); postpartum information for patient 2 is not available. All pregnancies resulted in live births. Infant 2 was born prematurely (34+3 weeks) and admitted to NICU for blood glucose monitoring and feeding support. Infant 4 experienced severe combined immunodeficiency due to in-utero azathioprine exposure. Pregnancy outcomes are summarized in Table 1. Table 1: Pregnancy Outcomes and Management in Pregnant Women Diagnosed with Dermatomyositis Conclusion In our case series of 6 pregnant patients with DM, all resulted in live births, although pregnancy complications were noted. Further studies on the effect of inflammatory myositis on pregnancy and vice versa are needed.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".