Distinct endothelial cells in chronic thromboembolic pulmonary hypertension
Bibliographic record
Abstract
Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening condition characterized by unresolved thrombi obstructing the pulmonary arteries. Endothelial cells (ECs) are essential regulators of thrombosis and thrombus resolution, yet their molecular phenotypes in CTEPH are incompletely understood. Using single-cell RNA sequencing of CTEPH surgical specimens and control ECs from the Human Lung Cell Atlas, we uncover marked EC heterogeneity in CTEPH. Compared to controls, CTEPH ECs display marked phenotypic shifts, with the loss and emergence of distinct EC subpopulations, including a unique subset co-expressing pulmonary and bronchial EC markers. Our analysis reveals perturbed endothelial thrombosis regulation, encompassing coagulation, fibrinolysis, inflammation, TGF-β signaling, and angiogenesis, while identifying novel target genes. These findings provide a comprehensive view of endothelial contributions to delayed thrombus resolution, offering new insights into the pathophysiology of CTEPH and potential therapeutic targets.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".