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Record W4411962665 · doi:10.1186/s13098-025-01815-4

The association between alcohol and metabolic syndrome: a systematic review and meta-analysis

2025· review· en· W4411962665 on OpenAlexaboutno aff
Maedeh Arshadi, Elahe Mansouri Yekta, Maryam Kazemi, Elham Khaledi, Zahra Beygi, Hosein Azizi, Farzad Khodamoradi

Bibliographic record

VenueDiabetology & Metabolic Syndrome · 2025
Typereview
Languageen
FieldMedicine
TopicAlcohol Consumption and Health Effects
Canadian institutionsnot available
Fundersnot available
KeywordsMedicineMeta-analysisAlcoholDiabetes mellitusMetabolic syndromeAssociation (psychology)BioinformaticsInternal medicineEndocrinologyPsychotherapistBiochemistryBiology

Abstract

fetched live from OpenAlex

BACKGROUND: Some studies have shown that there is a relationship between alcohol and metabolic syndrome, and some studies have not found an association; considering the importance of this issue, the aim of this study is to review all the studies related to alcohol and its relationship with metabolic syndrome and to update the information. METHODS: PubMed, Scopus and Web of Science were searched to identify studies on the association between alcohol and metabolic syndrome from January 1, 2000 through August 13, 2023. The pooled OR and the 95% confidence intervals were used to measure the association between alcohol and metabolic syndrome by assuming a random effects meta-analytic model. Quality appraisal was undertaken using the Newcastle-Ottawa Scale. RESULTS: A total of 62 studies were included. In the association between use of alcohol and metabolic syndrome, the pooled OR for cross-sectional studies was 1.12 [95% CI: 1.07, 1.18] and the pooled OR for cohort studies was 1.12 [95% CI: 1.06, 1.18]. In cohort and cross-sectional studies, the association between alcohol dose and metabolic syndrome, was not significant. For the association between frequency of alcohol consumption and metabolic syndrome, the pooled OR for under 1 to 2 times a week, 2 times to 7 times a week and above 7 drink/week were 0.85 [95% CI: 0.78, 0.93], 0.80 [95% CI: 0.63, 1.01] and 1.02 [95% CI: 0.41, 2.56], respectively. CONCLUSION: This study showed a positive relationship between alcohol consumption and metabolic syndrome. Therefore, it is recommended that further studies be conducted to accurately evaluate alcohol consumption and metabolic syndrome components, and for evaluate reducing or stopping alcohol consumption on metabolic syndrome, it is better to conduct clinical trial studies in the future.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.017
metaresearch head score (Gemma)0.041
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Meta-analysis · Consensus signal: Meta-analysis
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.021
Threshold uncertainty score0.090

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0170.041
Meta-epidemiology (narrow)0.0030.002
Meta-epidemiology (broad)0.0210.038
Bibliometrics0.0100.010
Science and technology studies0.0010.001
Scholarly communication0.0030.002
Open science0.0020.002
Research integrity0.0020.002
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.103
GPT teacher head0.407
Teacher spread0.304 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designMeta-analysis
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2025
Admission routes1
Has abstractyes

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