Serum Ferritin in Women With <i>HFE</i> p.C282Y Homozygosity: Positive Associations With Age, Live Births, Menopause, and Transferrin Saturation
Bibliographic record
Abstract
ABSTRACT Background We sought to determine associations of serum ferritin (SF) with live birth numbers and other iron‐related variables in women with HFE p.C282Y (rs1800562) homozygosity. Methods We studied non‐pregnant, non‐Hispanic white women in post‐screening evaluations to determine associations of SF with age, pregnancy and live birth numbers, dichotomous menopause and therapeutic phlebotomy reports, daily food and supplemental iron intakes, and transferrin saturation (TS). Results There were 136 women with mean age 51 ± 13 (SD) years and median SF 238 µg/L (range: 8, 2960). There were 376 pregnancies (median: 3/woman (1, 8)) and 296 live births (median: 2/woman (0, 6)). A total of 70 women (51.5%) reported menopause and 31 women (22.8%) reported phlebotomy. Median heme + non‐heme food iron intake was 13.4 mg/d (3.1, 57.3). Mean TS was 62 ± 25%. Pearson's coefficient of ln SF versus age was 0.1955 ( p = 0.0226). Median SF of women with and without menopause was 386 µg/L (8, 2960) and 165 µg/L (8, 1894), respectively ( p < 0.0002). SF associations with phlebotomy and iron intakes were not significant. Spearman's coefficient of SF versus TS was 0.5079 ( p < 0.0001). Four mean ln SF values of 66 women without menopause subgrouped by live birth numbers were similar (one‐way ANOVA p = 0.4460). Multiple regressions on SF using pregnancy numbers revealed positive associations with menopause ( p = 0.0157) and TS ( p < 0.0001) and using live birth numbers revealed positive associations with live births ( p = 0.0389), menopause ( p = 0.0305), and TS ( p < 0.0001). Conclusions SF levels in 136 women with p.C282Y homozygosity are positively associated with age, numbers of live births, menopause reports and TS.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".