Sedentary behaviors, physical activity, and risk of allergic rhinitis and asthma: evidence from cohort and Mendelian randomization studies
Bibliographic record
Abstract
BACKGROUND: The causality between movement behaviors [sedentary behavior (SB) and physical activity (PA)] with the prevalence of allergic rhinitis (AR) and asthma remained unclear. This study aimed to examine whether different movement behaviors are risk factors for AR and asthma based on epidemiological and genetic evidence, and to characterize these associations in diverse populations. METHODS: Based on information of questionnaires and registrations provided by UK Biobank, and large-scale GWAS (Genome-Wide Association Study) data, we designed a cohort study with a follow-up period exceeding 11 years and two-sample Mendelian randomization (MR) analysis to explore the causal associations between movement behaviors (SB and PA) and AR and asthma. RESULTS: Compared to participants with low SB, those with increased SB had higher risk for asthma (moderate: HR = 1.04, 95% CI: 1.01–1.08, p = 0.019; high: HR = 1.14, 95% CI: 1.10–1.18, p < 0.001). In contrast, more PA was a preventive factor for asthma (moderate: HR = 0.89, 95% CI: 0.81–0.97, p = 0.006; high: HR = 0.9, 95% CI: 0.83–0.99, p = 0.026). However, no correlation was found between movement behaviors and AR. The consistent associations between movement behaviors and asthma were also confirmed in male, younger (< 60) and older ( > = 60) populations. However, in females, only an association between SB and increased asthma risk was observed, while no protective effect of PA on asthma was identified. Moreover, genetically-predicted causality was observed between SB and asthma as well as PA and asthma by MR analysis (SB: OR = 1.16, 95% CI: 1.04–1.29, p = 0.009; PA: OR = 0.94, 95% CI: 0.88-1.00, p = 0.046), which was consistent with the findings of our cohort studies. CONCLUSIONS: This study highlights the risk of asthma associated with SB and emphasizes the role of PA in mitigating this risk. However, no significant association was found between movement behaviors and AR. CLINICAL TRIAL NUMBER: Not applicable.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.043 | 0.101 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.005 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".